Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.
Department of Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Semin Arthritis Rheum. 2017 Oct;47(2):175-182. doi: 10.1016/j.semarthrit.2017.04.002. Epub 2017 Apr 18.
To summarize, from the literature, quality-of-life (QoL) domains and items relevant to patients with spondyloarthritis (SpA), and to determine if commonly used SpA patient-reported outcome (PRO) instruments include the identified domains.
We used PRISMA statement for systematic review and searched Medline , Embase, and PsycInfo using relevant keywords. In addition, hand searches of references of the included articles were conducted. All articles were reviewed for inclusion by 2 independent reviewers. QoL domains and items relevant to patients with axial or peripheral SpA were extracted and presented using the adapted World Health Organization Quality-of-Life (WHOQOL) domain framework. SpA PROs were assessed to determine if they included the domains identified.
We retrieved 14,343 articles, of which 34 articles fulfilled inclusion criteria for review. Twenty-five articles were conducted in the European population. Domains such as negative feelings and activities of daily living were found to be present in 28 and 27 articles, respectively. SpA impacted QoL in all domains of the adapted WHOQOL framework. Domains that differed between types of SpA were financial resources, general levels of independence and medication side effects. Embarrassment, self-image, and premature ageing were items that differed by geographical setting. PROs to capture domains for peripheral SpA were similar for axial SpA.
We found that a wide range of domains and items of QoL were relevant to patients with SpA with minimal differences between patients with axial and peripheral SpA. Clinicians may consider using peripheral SpA PROs to measure QoL of patients with axial SpA.
从文献中总结出与脊柱关节炎（SpA）患者相关的生活质量（QoL）领域和项目，并确定常用的 SpA 患者报告结局（PRO）工具是否包含已确定的领域。
我们使用 PRISMA 声明进行系统评价，并使用相关关键词在 Medline、Embase 和 PsycInfo 中进行搜索。此外，还对纳入文章的参考文献进行了手工搜索。由 2 名独立评审员对所有文章进行纳入审查。提取与轴向或外周 SpA 患者相关的 QoL 领域和项目，并使用改编的世界卫生组织生活质量（WHOQOL）领域框架进行呈现。评估 SpA PRO 以确定它们是否包含已确定的领域。
我们检索到 14343 篇文章，其中 34 篇文章符合纳入审查标准。25 篇文章在欧洲人群中进行。分别有 28 篇和 27 篇文章发现存在负面感受和日常生活活动等领域。SpA 对改编的 WHOQOL 框架的所有领域的 QoL 都有影响。不同类型的 SpA 之间存在差异的领域包括财务资源、一般独立性水平和药物副作用。尴尬、自我形象和早衰是因地理位置不同而不同的项目。用于捕获外周 SpA 领域的 PRO 与轴向 SpA 的相似。
我们发现，广泛的 QoL 领域和项目与 SpA 患者相关，轴向和外周 SpA 患者之间的差异很小。临床医生可能会考虑使用外周 SpA PRO 来衡量轴向 SpA 患者的 QoL。
