Tyrovolas Stefanos, Koyanagi Ai, Kotsakis Georgios A, Panagiotakos Demosthenes, Shivappa Nitin, Wirth Michael D, Hébert James R, Haro Josep Maria
Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.
Parc Sanitari Sant Joan de Déu, Universitat de Barcelona, Fundació Sant Joan de Déu, Barcelona, Spain; Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, Spain.
Int J Cardiol. 2017 Aug 1;240:409-413. doi: 10.1016/j.ijcard.2017.04.104. Epub 2017 May 1.
Dietary guidelines are a key tool in the public health quiver. Single nutrients have been linked to cardiovascular diseases, but existing metrics do not capture the overall effect of diet on inflammatory diseases. The aim of this study was to examine the association between dietary inflammatory potential and cardiovascular diseases risk factors (CVD-RFs) in a nationally-representative sample of non-institutionalized US adults using data from the continuous National Health and Nutrition Examination Survey (NHANES) (2007-2012).
A sample of 7880 non-institutionalized US adults aged ≥20years provided data on dietary habits and CVD-RFs (obesity; diabetes mellitus; hypertension; hypercholesterolemia). The total number of CVD-RFs was summed for each individual to create a CVD-RF morbidity index (range 0-4) as the outcome variable, used both as ordinal and dichotomous (no CVD-RFs versus at least one CVD-RF) variables. The association between the Dietary Inflammatory Index (DII) and at least one CVD-RF was dose-dependent, with participants in the 3rd and 4th quartile of DII (i.e., more pro-inflammatory dietary habits) being 1.37 (95%CI=1.11-1.68) and 1.50 (95%CI=1.19-1.90) times more likely, respectively, to have at least one CVD-RF, as compared to participants in the 1st quartile of DII scores. Similar results were obtained for the ordinal logistic regression using the CVD-RF morbidity index as the outcome.
Among US adults aged ≥20years, pro-inflammatory dietary patterns, as assessed by the DII, were associated with increased odds for CVD-RFs. Dietary guidelines aimed at lowering the DII may reduce the CVD-RF burden in US adults.
饮食指南是公共卫生领域的一项关键工具。单一营养素已被证明与心血管疾病有关，但现有的衡量指标并未涵盖饮食对炎症性疾病的整体影响。本研究的目的是利用连续的国家健康和营养检查调查（NHANES）（2007 - 2012年）的数据，在全国代表性的非机构化美国成年人样本中，研究饮食炎症潜能与心血管疾病风险因素（CVD - RFs）之间的关联。
7880名年龄≥20岁的非机构化美国成年人提供了饮食习惯和CVD - RFs（肥胖、糖尿病、高血压、高胆固醇血症）的数据。计算每个个体的CVD - RFs总数，以创建一个CVD - RF发病指数（范围0 - 4）作为结果变量，该变量既用作有序变量，也用作二分变量（无CVD - RFs与至少有一个CVD - RF）。饮食炎症指数（DII）与至少一个CVD - RF之间的关联呈剂量依赖性，DII处于第三和第四四分位数的参与者（即具有更多促炎饮食习惯）分别比DII得分处于第一四分位数的参与者有至少一个CVD - RF的可能性高1.37倍（95%CI = 1.11 - 1.68）和1.50倍（95%CI = 1.19 - 1.90）。使用CVD - RF发病指数作为结果进行有序逻辑回归也得到了类似结果。
在年龄≥20岁的美国成年人中，通过DII评估的促炎饮食模式与CVD - RFs的患病几率增加有关。旨在降低DII的饮食指南可能会减轻美国成年人的CVD - RF负担。
