Rezaei Razieh, Safaei Mohsen, Mozaffari Hamid Reza, Moradpoor Hedaiat, Karami Sara, Golshah Amin, Salimi Behroz, Karami Hossein
Advanced Dental Sciences Research Laboratory, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Medical Biology Research Centre, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Open Access Maced J Med Sci. 2019 Jun 14;7(11):1884-1890. doi: 10.3889/oamjms.2019.486. eCollection 2019 Jun 15.
Nanotechnology has been widely exploited in recent years in various applications. Different sectors of medicine and treatment have also focused on the use of nanoproducts. One of the areas of interest in the treatment measures is the interaction between nanomaterials and immune system components. Engineered nanomaterials can stimulate the inhibition or enhancement of immune responses and prevent the detection ability of the immune system. Changes in immune function, in addition to the benefits, may also lead to some damage. Therefore, adequate assessment of the novel nanomaterials seems to be necessary before practical use in treatment. However, there is little information on the toxicological and biological effects of nanomaterials, especially on the potential ways of contacting and handling nanomaterials in the body and the body response to these materials. Extensive variation and different properties of nanomaterials have made it much more difficult to access their toxicological effects to the present. The present study aims to raise knowledge about the potential benefits and risks of using the nanomaterials on the immune system to design and safely employ these compounds in therapeutic purposes.
近年来，纳米技术已在各种应用中得到广泛应用。医学和治疗的不同领域也专注于纳米产品的使用。治疗措施中一个感兴趣的领域是纳米材料与免疫系统成分之间的相互作用。工程纳米材料可以刺激免疫反应的抑制或增强，并阻止免疫系统的检测能力。免疫功能的变化，除了带来益处外，也可能导致一些损害。因此，在实际用于治疗之前，似乎有必要对新型纳米材料进行充分评估。然而，关于纳米材料的毒理学和生物学效应的信息很少，特别是关于纳米材料在体内接触和处理的潜在方式以及身体对这些材料的反应。纳米材料的广泛变化和不同特性使得目前了解它们的毒理学效应变得更加困难。本研究旨在提高对使用纳米材料对免疫系统的潜在益处和风险的认识，以便在治疗目的中设计和安全使用这些化合物。
