Ahmed Sarfaraz, Yousaf Muhammad, Mothana Ramzi A, Al-Rehaily Adnan J
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Afr J Tradit Complement Altern Med. 2016 Aug 12;13(5):145-152. doi: 10.21010/ajtcam.v13i5.19. eCollection 2016.
Plants of are used in folkloric medicines in variety of ailments and well known for chemical diversity of their isoprenoid constituents. This study was carried out to explore the preliminary wound healing potential of four species ( 1, 2, , and ).
Excision wound surface of the animals were topically treated with ethyl acetate and methanol extracts of plants at a dose of 400 mg/kg body weight for twenty days. Povidone-iodine ointment was used as a reference drug. Wound contraction measurement and period of epithelialization were used to assess the effect of plants extracts on wound repairing.
The groups treated with methanol extracts of and showed profound effects, high rate of wound contraction (100%) and decrease in epithelization period 19.00±0.40 and 18.50±0.64 respectively, followed by methanol extracts of 2, ethyl acetate extract of and ethyl acetate extracts of 2 which showed significant ( <0.001) wound contraction and decrease in epithelization period. Conversely ethyl acetate extract of 1, and and methanol extract of 1 and treated groups was not showing significant wound healing. Methanol extracts of and were also tested for their safety margin and found safe up to dose of 2000mg/kg body weight.
Topical application of methanol extracts of E. balsamifera and E. schimperi have potential wound healing activity which is identical with standard drug Povidone-iodine.
[植物名称]植物被用于多种民间药物治疗各种疾病，并以其类异戊二烯成分的化学多样性而闻名。本研究旨在探索四种[植物名称]物种（[物种1]、[物种2]、[物种3]和[物种4]）初步的伤口愈合潜力。
以400mg/kg体重的剂量，用植物的乙酸乙酯和甲醇提取物对动物的切除伤口表面进行局部治疗，持续20天。聚维酮碘软膏用作参考药物。通过伤口收缩测量和上皮形成期来评估植物提取物对伤口修复的影响。
用[物种1]和[物种2]的甲醇提取物处理的组显示出显著效果，伤口收缩率高（100%），上皮形成期分别缩短至19.00±0.40和18.50±0.64，其次是[物种2]的甲醇提取物、[物种3]的乙酸乙酯提取物和[物种2]的乙酸乙酯提取物，它们显示出显著的（P<0.001）伤口收缩和上皮形成期缩短。相反，[物种1]、[物种3]和[物种4]的乙酸乙酯提取物以及[物种1]和[物种4]的甲醇提取物处理组未显示出显著的伤口愈合效果。还对[物种1]和[物种2]的甲醇提取物进行了安全范围测试，发现其在高达2000mg/kg体重的剂量下是安全的。
局部应用香脂香胶树和施氏香胶树的甲醇提取物具有潜在的伤口愈合活性，与标准药物聚维酮碘相同。
