McManus K, Wood A, Wright M H, Matthews B, Greene A C, Cock I E
School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, Qld, 4111, Australia.
Division of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University, Portland, OR, 97239, USA.
Int J Cosmet Sci. 2017 Oct;39(5):500-510. doi: 10.1111/ics.12403. Epub 2017 Jul 5.
Terminalia ferdinandiana extracts are potent growth inhibitors of many bacterial pathogens. They may also inhibit the growth of malodour-producing bacteria and thus be useful deodorant components, although this is yet to be tested.
Terminalia ferdinandiana fruit and leaf solvent extracts were investigated by disc diffusion and liquid dilution MIC assays against the most significant bacterial contributors to axillary and plantar malodour formation. Toxicity was determined using the Artemia franciscana nauplii bioassay. Non-targeted HPLC separation of the methanolic leaf extract coupled to high-resolution time-of-flight (TOF) mass spectroscopy was used for the identification and characterization of individual components in the extract.
The T. ferdinandiana leaf extracts were the most potent bacterial growth inhibitors. The leaf methanolic extract was particularly potent, with low MIC values against C. jeikeium (233 μg mL ), S. epidermidis (220 μg mL ), P. acnes (625 μg mL ) and B. linens (523 μg mL ). The aqueous and ethyl acetate leaf extracts were also potent growth inhibitors of C. jeikeium and S. epidermidis (MICs < 1000 μg mL ). In comparison, the fruit extracts were substantially less potent antibacterial agents, although still with MIC values indicative of moderate growth inhibitory activity. All T. ferdinandiana leaf extracts were non-toxic in the Artemia franciscana bioassay. Non-biased phytochemical analysis of the methanolic leaf extract revealed the presence of high levels of and high diversity of tannins and high levels of the flavone luteolin.
The low toxicity of the T. ferdinandiana leaf extracts and their potent growth inhibition of axillary and plantar malodour-producing bacteria indicate their potential as deodorant components.
费氏榄仁提取物是多种细菌病原体的强效生长抑制剂。它们也可能抑制产生恶臭的细菌生长，因此可能是有用的除臭剂成分，尽管这还有待测试。
通过纸片扩散法和液体稀释微量肉汤稀释法，研究费氏榄仁果实和叶片的溶剂提取物对导致腋窝和足底恶臭形成的最重要细菌的抗菌活性。使用卤虫无节幼体生物测定法测定毒性。采用甲醇叶提取物的非靶向高效液相色谱分离结合高分辨率飞行时间质谱，对提取物中的各个成分进行鉴定和表征。
费氏榄仁叶提取物是最有效的细菌生长抑制剂。叶甲醇提取物特别有效，对杰氏棒状杆菌（233μg/mL）、表皮葡萄球菌（220μg/mL）、痤疮丙酸杆菌（625μg/mL）和亚麻短杆菌（523μg/mL）的最低抑菌浓度较低。水提物和乙酸乙酯叶提取物也是杰氏棒状杆菌和表皮葡萄球菌的强效生长抑制剂（最低抑菌浓度<1000μg/mL）。相比之下，果实提取物作为抗菌剂的效力要低得多，尽管其最低抑菌浓度仍表明具有中等生长抑制活性。在卤虫生物测定中，所有费氏榄仁叶提取物均无毒。甲醇叶提取物的非偏向性植物化学分析显示，含有高水平且高度多样的单宁以及高水平的黄酮木犀草素。
费氏榄仁叶提取物的低毒性及其对腋窝和足底产生恶臭细菌的强效生长抑制作用表明它们有作为除臭剂成分的潜力。
