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用于无散射箔自由电子束扫描技术的蒙特卡罗模拟：概念验证研究。

Monte Carlo simulation for scanning technique with scattering foil free electron beam: A proof of concept study.

作者信息

Sung Wonmo, Park Jong In, Kim Jung-In, Carlson Joel, Ye Sung-Joon, Park Jong Min

机构信息

Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Seoul National University Graduate School of Convergence Science and Technology, Seoul, Republic of Korea.

Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea.

出版信息

PLoS One. 2017 May 11;12(5):e0177380. doi: 10.1371/journal.pone.0177380. eCollection 2017.

DOI:10.1371/journal.pone.0177380
PMID:28493940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5426680/
Abstract

This study investigated the potential of a newly proposed scattering foil free (SFF) electron beam scanning technique for the treatment of skin cancer on the irregular patient surfaces using Monte Carlo (MC) simulation. After benchmarking of the MC simulations, we removed the scattering foil to generate SFF electron beams. Cylindrical and spherical phantoms with 1 cm boluses were generated and the target volume was defined from the surface to 5 mm depth. The SFF scanning technique with 6 MeV electrons was simulated using those phantoms. For comparison, volumetric modulated arc therapy (VMAT) plans were also generated with two full arcs and 6 MV photon beams. When the scanning resolution resulted in a larger separation between beams than the field size, the plan qualities were worsened. In the cylindrical phantom with a radius of 10 cm, the conformity indices, homogeneity indices and body mean doses of the SFF plans (scanning resolution = 1°) vs. VMAT plans were 1.04 vs. 1.54, 1.10 vs. 1.12 and 5 Gy vs. 14 Gy, respectively. Those of the spherical phantom were 1.04 vs. 1.83, 1.08 vs. 1.09 and 7 Gy vs. 26 Gy, respectively. The proposed SFF plans showed superior dose distributions compared to the VMAT plans.

摘要

本研究使用蒙特卡罗（MC）模拟，探究了一种新提出的无散射箔（SFF）电子束扫描技术在治疗不规则患者体表皮肤癌方面的潜力。在对MC模拟进行基准测试后，我们移除了散射箔以产生SFF电子束。生成了带有1厘米 bolus 的圆柱形和球形体模，并将靶区体积定义为从表面到5毫米深度。使用这些体模模拟了6兆电子伏电子的SFF扫描技术。为作比较，还使用两个全弧和6兆伏光子束生成了容积调强弧形治疗（VMAT）计划。当扫描分辨率导致束间间距大于射野尺寸时，计划质量会变差。在半径为10厘米的圆柱形体模中，SFF计划（扫描分辨率 = 1°）与VMAT计划的适形指数、均匀性指数和体平均剂量分别为1.04对1.54、1.10对1.12以及5戈瑞对14戈瑞。球形体模的相应数值分别为1.04对1.83、1.08对1.09以及7戈瑞对26戈瑞。与VMAT计划相比，所提出的SFF计划显示出更优的剂量分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/6b0b3a792319/pone.0177380.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/1797d474719a/pone.0177380.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/080374952b73/pone.0177380.g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/be0aefa68bad/pone.0177380.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/ec09b8a9291f/pone.0177380.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/e48dad47d707/pone.0177380.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/4491f488e4cb/pone.0177380.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/155b9b2ed76b/pone.0177380.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/6b0b3a792319/pone.0177380.g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/1797d474719a/pone.0177380.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/7ab8e7c33110/pone.0177380.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/d4969476a09c/pone.0177380.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/080374952b73/pone.0177380.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/63e46845a74a/pone.0177380.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/be0aefa68bad/pone.0177380.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/ec09b8a9291f/pone.0177380.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/c84704c3add0/pone.0177380.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/e48dad47d707/pone.0177380.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/4491f488e4cb/pone.0177380.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/155b9b2ed76b/pone.0177380.g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3583/5426680/6b0b3a792319/pone.0177380.g012.jpg

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