使用一种新的快速检测方法iART监测流感病毒对奥司他韦的敏感性。
Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART.
作者信息
Gubareva Larisa V, Fallows Eric, Mishin Vasiliy P, Hodges Erin, Brooks Abdullah, Barnes John, Fry Alicia M, Kramp William, Shively Roxanne, Wentworth David E, Weidemaier Kristin, Jacobson Ross
机构信息
Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention (CDC), Atlanta, GA, United States.
Becton Dickinson, Research Triangle Park, North Carolina, United States.
出版信息
Euro Surveill. 2017 May 4;22(18). doi: 10.2807/1560-7917.ES.2017.22.18.30529.
A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.
一种用于检测流感病毒中对奥司他韦耐药性的新型快速检测方法——iART，被用于检测149份临床样本。132份样本获得了检测结果，iART显示其中41份为“耐药”。对于这些样本，序列分析发现了奥司他韦耐药的已知和疑似标志物，而其余91份样本未检测到此类标志物。从41份样本中分离出的病毒在神经氨酸酶抑制试验中显示出抑制作用降低或高度降低。iART可能有助于更广泛的抗病毒耐药性检测。
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