Sharifzadeh Mohammad, Ranjbar Akram, Hosseini Asieh, Khanavi Mahnaze
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Toxicology and Pharmacology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
Iran J Pharm Res. 2017 Winter;16(1):201-209.
Diabetes mellitus is associated with distribution of cognitive functioning. Hyperglycemia induced oxidative stress has been proposed as a cause of memory complications of diabetes including cognitive impairment. The aim of this study was to examine total green tea extract (TGTE), a potent free radical scavenger against spatial impairment in Streptozotocin-diabetic rats. Eight weeks after diabetes induction, TGTE was administrated throught drinking water 3 mg/L. The learning and memory behavior was evaluated with Morris water maze task in male rats. Then, for estimation of oxidative stress parameters such as lipid peroxidation (LPO), total antioxidant capacity (FRAP) and total thiol groups in blood were measured. The total green tea extract showed improved cognitive impairment in diabetic groups but these changes weren't significant. There was also significant increase FRAP level and total thiol groups in treated green tea groups vs.
group. This study demonstrated the effectiveness of TGTE on spatial impairment and oxidative stress induced in diabetes mellitus.
糖尿病与认知功能分布有关。高血糖诱导的氧化应激被认为是糖尿病记忆并发症（包括认知障碍）的一个原因。本研究的目的是研究总绿茶提取物（TGTE），一种针对链脲佐菌素诱导的糖尿病大鼠空间损伤的有效自由基清除剂。糖尿病诱导8周后，通过饮用水给予TGTE 3mg/L。用Morris水迷宫任务评估雄性大鼠的学习和记忆行为。然后，测量血液中的氧化应激参数，如脂质过氧化（LPO）、总抗氧化能力（FRAP）和总巯基。总绿茶提取物在糖尿病组中显示出改善的认知障碍，但这些变化不显著。与对照组相比，治疗绿茶组的FRAP水平和总巯基也有显著增加。
本研究证明了TGTE对糖尿病诱导的空间损伤和氧化应激的有效性。
