水下 Leidenfrost 纳米化学用于定制尺寸的过氧化锌癌症纳米治疗。
Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics.
机构信息
Nanochemistry and Nanoengineering, School of Chemical Engineering, Department of Chemistry and Materials Science, Aalto University, Kemistintie 1, 00076 Aalto, Finland.
Nanochemistry and Nanoengineering, Institute for Materials Science, Faculty of Engineering, Kiel University, Kaiserstrasse 2, 24143 Kiel, Germany.
出版信息
Nat Commun. 2017 May 12;8:15319. doi: 10.1038/ncomms15319.
The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.
自然界中所见的动态水下化学为下一代环保型纳米化学提供了灵感。在这种情况下，通过动态过程以简单且可扩展的方式进行尺寸可调的纳米粒子的绿色合成是一个有趣的挑战。模拟深海火山诱导的动态化学，本文中我们展示了在水下过热受限区域中发生的 Leidenfrost 动态化学，将其作为定制生成过氧化锌纳米团簇的新工具。该现象的流体动力性质确保了纳米团簇向更冷区域的喷发，从而生长出单分散、尺寸可调的纳米团簇。研究人员还研究了这些纳米颗粒在悬浮和贴壁细胞中的细胞毒性，以证明它们作为癌症纳米治疗剂的适用性。我们的研究可以为动态绿色纳米化学在生物医学应用中简便、可扩展地制造尺寸可调的纳米颗粒铺平道路。
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