Zhang Yu, Liu Jun, Li Sha, Zhou Jinhua, Liu Jiushan, Huang Yan
Department of Emergency, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha), Changsha, Hunan, China.
Front Bioeng Biotechnol. 2025 May 20;13:1608188. doi: 10.3389/fbioe.2025.1608188. eCollection 2025.
Functional nanomaterials based on reactive oxygen species (ROS) have attracted considerable attention in the treatment of bacterial infections, owing to their high sterilization efficiency and low tendency to induce drug resistance. Natural polymers, known for their excellent biocompatibility, have been widely used in the development of antibacterial dressings. In this study, chitosan-zinc peroxide composite dressing (CS@ZnO) was synthesized using zinc acetate and chitosan as primary raw materials, and comprehensive characterizations were performed. Under the slightly acidic conditions of bacterial infections, CS@ZnO could self-decompose to release HO and produce large amount of ROS, which would cause damage to bacteria. The antibacterial properties of CS@ZnO were investigated using (. ) and (. ) as representative pathogens. The results demonstrated that CS@ZnO exhibited potent antibacterial efficacy against both . and . . This research provides an important theoretical foundation and technical support for the development of novel antibacterial materials, and has the potential to improve the efficacy of treatments for bacterial infections in the future.
基于活性氧（ROS）的功能纳米材料因其高杀菌效率和低耐药诱导倾向，在细菌感染治疗中受到了广泛关注。天然聚合物以其优异的生物相容性而闻名，已被广泛应用于抗菌敷料的开发。在本研究中，以醋酸锌和壳聚糖为主要原料合成了壳聚糖-过氧化锌复合敷料（CS@ZnO），并进行了全面表征。在细菌感染的微酸性条件下，CS@ZnO可自分解释放HO并产生大量ROS，从而对细菌造成损伤。以（. ）和（. ）作为代表性病原体研究了CS@ZnO的抗菌性能。结果表明，CS@ZnO对（. ）和（. ）均表现出强大的抗菌效果。本研究为新型抗菌材料的开发提供了重要的理论基础和技术支持，并有望在未来提高细菌感染的治疗效果。
