用于癌症治疗的金属过氧化物。

Metal peroxides for cancer treatment.

作者信息

He Jin, Fu Lian-Hua, Qi Chao, Lin Jing, Huang Peng

机构信息

Marshall Laboratory of Biomedical Engineering, International Cancer Center, Laboratory of Evolutionary Theranostics (LET), School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.

Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, China.

出版信息

Bioact Mater. 2021 Feb 13;6(9):2698-2710. doi: 10.1016/j.bioactmat.2021.01.026. eCollection 2021 Sep.

In recent years, metal peroxide (MO) such as CaO has received more and more attention in cancer treatment. MO is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment (TME), resulting metal ions overloading, decreased acidity and elevated oxidative stress in TME. All of these changes making MO an excellent tumor therapeutic agent. Moreover, by combining MO with photosensitizers, enzymes or Fenton reagents, MO can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy. In this review, the synthesis and modification methods of MO are introduced, and the representative studies of MO-based tumor monotherapy and combination therapy are discussed in detail. Finally, the current challenges and prospects of MO in the field of tumor therapy are emphasized to promote the development of MO-based cancer treatment.

近年来，金属过氧化物（如CaO）在癌症治疗中受到越来越多的关注。金属过氧化物在酸性肿瘤微环境（TME）中容易分解，释放出金属离子和过氧化氢，导致TME中金属离子过载、酸度降低和氧化应激升高。所有这些变化使金属过氧化物成为一种出色的肿瘤治疗剂。此外，通过将金属过氧化物与光敏剂、酶或芬顿试剂结合，金属过氧化物可以辅助和促进各种肿瘤治疗，如光动力疗法和化学动力疗法。在这篇综述中，介绍了金属过氧化物的合成和修饰方法，并详细讨论了基于金属过氧化物的肿瘤单一疗法和联合疗法的代表性研究。最后，强调了金属过氧化物在肿瘤治疗领域当前面临的挑战和前景，以促进基于金属过氧化物的癌症治疗的发展。