Brassard Patrice, Tymko Michael M, Ainslie Philip N
Department of Kinesiology, Faculty of Medicine, Université Laval, Québec, Canada; Research Center of the Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada.
Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada.
Auton Neurosci. 2017 Nov;207:37-47. doi: 10.1016/j.autneu.2017.05.003. Epub 2017 May 5.
Although the human cerebral circulation is richly innervated with sympathetic nerve fibers, the role of sympathetic nerve activity (SNA) on the regulation of cerebral blood flow (CBF) remains debated. Several issues may be responsible for the conflicting conclusions reported in the animal vs. human literature in regards to the sympathetic control of the brain circulation. Furthermore, due to the physiological consequences associated with SNA blockade (e.g. changes in blood pressure and cardiac output), and differences in methodology (e.g. assessment of CBF), interpretation of the role of SNA in CBF regulation in humans is challenging. The goals of this brief review are to provide an overview of the role of neural control in the regulation of CBF, with a focus on SNA and discuss the likely reasons behind the controversial influence of SNA on CBF regulation. A final objective of this article is to critically review the various methods available to measure CBF and highlight their strengths and weaknesses to provide insight in SNA regulation of CBF.
尽管人类脑循环富含交感神经纤维，但交感神经活动（SNA）对脑血流量（CBF）调节的作用仍存在争议。动物与人类文献中关于脑循环交感神经控制的结论相互矛盾，可能由几个问题导致。此外，由于SNA阻断会带来生理后果（如血压和心输出量的变化），以及方法学上的差异（如CBF评估），解读SNA在人类CBF调节中的作用具有挑战性。本简要综述的目的是概述神经控制在CBF调节中的作用，重点关注SNA，并讨论SNA对CBF调节产生争议性影响背后的可能原因。本文的最终目标是批判性地审视测量CBF的各种可用方法，突出其优缺点，以深入了解SNA对CBF的调节。
