念珠菌病：巴基斯坦一家三级医院的患病率及耐药性分析

Candidiasis: Prevalence and resistance profiling in a tertiary care hospital of Pakistan.

作者信息

Jamil Bushra, Mukhtar Bokhari Mohammad Tauseef, Saeed Azhar, Mukhtar Bokhari Mohammad Zahid, Hussain Zakir, Khalid Tayyaba, Bokhari Habib, Imran Mohammad, Abbasi Shahid Ahmad

机构信息

Department of Biosciences, COMSATS Institute of Information Technology, Islamabad.

Assistant Professor (Yusra Medical & Dental College). Al-Sayed Hospital (Pvt) Ltd. Rawalpindi.

出版信息

J Pak Med Assoc. 2017 May;67(5):688-697.

PMID:28507352

Abstract

OBJECTIVE

To determine Candida colonisation/infection in renal transplant patients and to determine the resistance pattern against antifungal drugs.

METHODS

This prospective, observational study was conducted at Al-Sayyed Hospital, Rawalpindi, Pakistan, from January to October 2014, in collaboration with the Microbiology and Public Health Laboratory's, Islamabad campus..The clinical specimens investigated included respiratory tract secretions, blood, urine, high vaginal swab, skin scrapings, and plastic devices samples.

RESULTS

Of the 7,850 samples, 164(2.08%) were positive for Candida. Candida albicans were most prevalent as they were found in 114(69%) samples. Besides, 56(34%) of the positive samples were resistant to one or more antifungal agents. Highest resistance was obtained against fluconazole. We found only 5(3.04%) positive samples of Candida glabrata; of them, 3(60%)were resistant. In case of Candida spp, 27(48%) resistance was observed. In Candida albicans, 23(41%) of the samples were found to be resistant. Most of the Candida isolates was recovered from bronchial alveolar lavage.

CONCLUSIONS

Although Candida albicans remained the main responsible species for Candida infections, but non-albican Candida species are also emerging.

摘要

目的

确定肾移植患者念珠菌的定植/感染情况，并确定其对抗真菌药物的耐药模式。

方法

这项前瞻性观察性研究于2014年1月至10月在巴基斯坦拉瓦尔品第的赛义德医院与伊斯兰堡校区的微生物学和公共卫生实验室合作进行。所调查的临床标本包括呼吸道分泌物、血液、尿液、高阴道拭子、皮肤刮屑和塑料装置样本。

结果

在7850份样本中，164份（2.08%）念珠菌检测呈阳性。白色念珠菌最为常见，在114份（69%）样本中被发现。此外，56份（34%）阳性样本对一种或多种抗真菌药物耐药。对氟康唑的耐药性最高。我们仅发现5份（3.04%）光滑念珠菌阳性样本；其中3份（60%）耐药。在念珠菌属中，观察到27份（48%）耐药。在白色念珠菌中，23份（41%）样本被发现耐药。大多数念珠菌分离株来自支气管肺泡灌洗。