• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

从短柄麦氏杆菌中分离并鉴定出导致细胞毒性和细胞周期停滞的邻苯二甲酸盐。

Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest.

作者信息

Rajamanikyam Maheshwari, Vadlapudi Varahalarao, Parvathaneni Sai Prathima, Koude Dhevendar, Sripadi Prabhakar, Misra Sunil, Amanchy Ramars, Upadhyayula Suryanarayana Murty

机构信息

Biology Division, CSIR-Indian Institute of Chemical Technology (IICT), Uppal Road, Tarnaka, Hyderabad -500 007, India.

Crop Protection Chemicals Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad -500 007, India.

出版信息

EXCLI J. 2017 Mar 24;16:375-387. doi: 10.17179/excli2017-145. eCollection 2017.

DOI:10.17179/excli2017-145
PMID:28507481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5427467/
Abstract

Bacteria belonging to the family Brevibacterieae are ubiquitous Gram positive organisms that are responsible for the feet odour and cheese aroma. is a relatively new member belonging to Brevibacterieae. In the current manuscript we discuss isolation of biologically active metabolites from . Two aromatic esters were isolated from by "Bioassay guided fractionation strategy" and identified as di-(2-ethylhexyl) phthalate and dibutyl phthalate by chemical characterization using biophysical techniques. The phthalate compounds show broad spectrum antibacterial activity and mosquito larvicidal activity. Mosquito larvicidal activity has been attributed to inhibition of acetylcholinesterase enzyme activity. These compounds were found to be cytotoxic in multiple cell lines causing cell cycle arrest in G1 phase.

摘要

短杆菌科细菌是普遍存在的革兰氏阳性菌，会导致脚臭和奶酪香气。[具体名称]是短杆菌科的一个相对新的成员。在当前的手稿中，我们讨论了从[具体名称]中分离生物活性代谢物的方法。通过“生物测定导向分级分离策略”从[具体名称]中分离出两种芳香酯，并使用生物物理技术通过化学表征鉴定为邻苯二甲酸二（2-乙基己基）酯和邻苯二甲酸二丁酯。邻苯二甲酸酯化合物具有广谱抗菌活性和杀蚊幼虫活性。杀蚊幼虫活性归因于对乙酰胆碱酯酶活性的抑制。这些化合物在多种细胞系中具有细胞毒性，导致细胞周期停滞在G1期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/82f833092ab7/EXCLI-16-375-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/c9299f529a4c/EXCLI-16-375-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/1f19240b3a47/EXCLI-16-375-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/fbeb690ab9d0/EXCLI-16-375-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/8a69ed4e9b7d/EXCLI-16-375-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/82f833092ab7/EXCLI-16-375-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/c9299f529a4c/EXCLI-16-375-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/1f19240b3a47/EXCLI-16-375-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/fbeb690ab9d0/EXCLI-16-375-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/8a69ed4e9b7d/EXCLI-16-375-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74a4/5427467/82f833092ab7/EXCLI-16-375-g-005.jpg

相似文献

1
Isolation and characterization of phthalates from Brevibacterium mcbrellneri that cause cytotoxicity and cell cycle arrest.从短柄麦氏杆菌中分离并鉴定出导致细胞毒性和细胞周期停滞的邻苯二甲酸盐。
EXCLI J. 2017 Mar 24;16:375-387. doi: 10.17179/excli2017-145. eCollection 2017.
2
Clastogenic, aneugenic, and tubulin polymerization properties of di-(2-ethylhexyl) phthalate and dibutyl phthalate.邻苯二甲酸二（2-乙基己基）酯和邻苯二甲酸二丁酯的致裂、变倍体和微管聚合性质。
Toxicol Ind Health. 2023 Sep;39(9):504-514. doi: 10.1177/07482337231182191. Epub 2023 Jul 12.
3
Effects of dibutyl phthalate and di(2-ethylhexyl) phthalate with their metabolites on CYP2C9*1 and CYP2C19*1 activities in vitro.邻苯二甲酸二丁酯和邻苯二甲酸二（2-乙基己基）酯及其代谢物对 CYP2C9*1 和 CYP2C19*1 体外活性的影响。
J Pharm Biomed Anal. 2018 Oct 25;160:195-201. doi: 10.1016/j.jpba.2018.07.055. Epub 2018 Aug 2.
4
Endoplasmic reticulum stress as a novel cellular response to di (2-ethylhexyl) phthalate exposure.内质网应激作为一种对邻苯二甲酸二（2-乙基己基）酯暴露的新型细胞反应。
Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):281-7. doi: 10.1016/j.tiv.2015.10.009. Epub 2015 Oct 26.
5
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain.
Bioorg Med Chem Lett. 2008 Mar 15;18(6):2083-8. doi: 10.1016/j.bmcl.2008.01.097. Epub 2008 Jan 30.
6
Brevibacterium massiliense sp. nov., isolated from a human ankle discharge.马西利亚短杆菌新种，从人类脚踝分泌物中分离得到。
Int J Syst Evol Microbiol. 2009 Aug;59(Pt 8):1960-4. doi: 10.1099/ijs.0.007864-0. Epub 2009 Jun 30.
7
Occurrence of phthalate esters in over-the-counter medicines from China and its implications for human exposure.邻苯二甲酸酯在我国非处方药物中的存在及其对人体暴露的影响。
Environ Int. 2017 Jan;98:137-142. doi: 10.1016/j.envint.2016.10.025. Epub 2016 Nov 3.
8
Exposure to phthalates in 5-6 years old primary school starters in Germany--a human biomonitoring study and a cumulative risk assessment.德国 5-6 岁小学新生邻苯二甲酸酯暴露情况——一项人体生物监测研究和累积风险评估。
Int J Hyg Environ Health. 2011 Jun;214(3):188-95. doi: 10.1016/j.ijheh.2011.01.009. Epub 2011 Mar 2.
9
Comparative uptake, translocation and subcellular distribution of phthalate esters and their primary monoester metabolites in Chinese cabbage (Brassica rapa var. chinensis).比较研究邻苯二甲酸酯及其主要单酯代谢物在白菜（ Brassica rapa var. chinensis ）中的吸收、迁移和亚细胞分布。
Sci Total Environ. 2020 Nov 10;742:140550. doi: 10.1016/j.scitotenv.2020.140550. Epub 2020 Jun 27.
10
An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study.一种将毒理基因组学数据整合到风险评估中的方法：以邻苯二甲酸二丁酯为例。
Toxicol Appl Pharmacol. 2013 Sep 15;271(3):324-35. doi: 10.1016/j.taap.2013.03.013. Epub 2013 Mar 26.

引用本文的文献

1
Purgative Effect, Acute Toxicity, and Quantification of Phorbol-12-Myristate-13-Acetate and Crotonic Acid in L. Seeds Before and After Treatment by Thai Traditional Detoxification Process.泰国传统解毒工艺处理前后巴豆种子中佛波醇-12-肉豆蔻酸酯-13-乙酸酯和巴豆酸的泻下作用、急性毒性及定量分析
Int J Mol Sci. 2025 Aug 9;26(16):7714. doi: 10.3390/ijms26167714.
2
LMY3-5 for the biocontrol of soft rot in kiwifruit: antifungal action and underlying mechanisms.用于猕猴桃软腐病生物防治的LMY3-5：抗真菌作用及潜在机制
Front Microbiol. 2025 Apr 29;16:1562366. doi: 10.3389/fmicb.2025.1562366. eCollection 2025.
3
Phytochemical and biological assessment of secondary metabolites isolated from a rhizosphere strain, Sphingomonas sanguinis DM of Datura metel.

本文引用的文献

1
Preparation of an adsorbent based on polymeric ionic liquid for the simultaneous extraction of acidic, basic and neutral pollutants.基于聚合离子液体的吸附剂的制备，用于同时萃取酸性、碱性和中性污染物。
J Chromatogr A. 2016 Sep 30;1466:42-9. doi: 10.1016/j.chroma.2016.09.011. Epub 2016 Sep 5.
2
Single-step biological fabrication of colloidal silver nanoparticles using Hugonia mystax: larvicidal potential against Zika virus, dengue, and malaria vector mosquitoes.利用 Hugonia mystax 一步法生物制备胶体银纳米粒子：对寨卡病毒、登革热和疟疾媒介蚊子的杀幼虫潜力。
Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1317-1325. doi: 10.1080/21691401.2016.1228664. Epub 2016 Sep 9.
3
从曼陀罗根际菌株血红色沙雷氏菌（Sphingomonas sanguinis DM）中分离得到的次生代谢产物的植物化学和生物评估。
BMC Complement Med Ther. 2024 May 25;24(1):205. doi: 10.1186/s12906-024-04482-6.
4
Sensitivity of Legionella pneumophila to phthalates and their substitutes.嗜肺军团菌对邻苯二甲酸酯及其替代品的敏感性。
Sci Rep. 2023 Dec 13;13(1):22145. doi: 10.1038/s41598-023-49426-1.
5
GC Analysis, Anticancer, and Antibacterial Activities of Secondary Bioactive Compounds from Endosymbiotic Bacteria of Pomegranate Aphid and Its Predator and Protector.石榴蚜及其捕食者和保护者内生细菌的次生生物活性化合物的 GC 分析、抗癌和抗菌活性。
Molecules. 2023 May 22;28(10):4255. doi: 10.3390/molecules28104255.
6
The Antibacterial and Larvicidal Potential of Bis-(2-Ethylhexyl) Phthalate from .双-(2-乙基己基)邻苯二甲酸酯的抗菌和杀幼虫潜力
Molecules. 2022 Oct 25;27(21):7220. doi: 10.3390/molecules27217220.
7
Development of Lateral Flow Test-System for the Immunoassay of Dibutyl Phthalate in Natural Waters.发展用于测定天然水中邻苯二甲酸二丁酯的免疫分析的侧向流动测试系统。
Biosensors (Basel). 2022 Nov 10;12(11):1002. doi: 10.3390/bios12111002.
8
Effects of 2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone from Seeds on Antiproliferative, DNA Damage, Cell Cycle Arrest, and Apoptosis in Human Cervical Cancer Cell Lines.2',4'-二羟基-6'-甲氧基-3',5'-二甲氧基查耳酮对人宫颈癌细胞系的增殖抑制、DNA 损伤、细胞周期阻滞和凋亡的影响。
Molecules. 2022 Feb 9;27(4):1154. doi: 10.3390/molecules27041154.
9
Characterization of Fatty Acids, Polysaccharides, Amino Acids, and Minerals in Marine Macroalga and Evaluation of Their Potentials in Skin Cosmetics.海洋大型藻类中脂肪酸、多糖、氨基酸和矿物质的特性及其在皮肤化妆品中的潜力评价。
Molecules. 2021 Dec 11;26(24):7515. doi: 10.3390/molecules26247515.
10
Tracing Poly(Vinyl Acetate) Emulsions by Infrared and Raman Spectroscopies: Identification of Spectral Markers.通过红外光谱和拉曼光谱追踪聚醋酸乙烯酯乳液：光谱标记物的鉴定
Polymers (Basel). 2021 Oct 20;13(21):3609. doi: 10.3390/polym13213609.
miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1.
miR-15a/miR-16 通过抑制癌基因 BMI1 诱导乳腺癌细胞线粒体依赖性凋亡。
Life Sci. 2016 Nov 1;164:60-70. doi: 10.1016/j.lfs.2016.08.028. Epub 2016 Sep 3.
4
Cytotoxic activity of Secondary Metabolites from Marine-derived Fungus Neosartorya siamensis in Human Cancer Cells.海洋来源真菌暹罗新萨托菌次生代谢产物对人癌细胞的细胞毒活性
Phytother Res. 2016 Nov;30(11):1862-1871. doi: 10.1002/ptr.5696. Epub 2016 Aug 17.
5
[Effects of long term and low dose Di- (2-ethylhexyl) phthalate exposure on global genome DNA methylation in HePG2 cells].长期低剂量邻苯二甲酸二（2-乙基己基）酯暴露对人肝癌细胞系HePG2全基因组DNA甲基化的影响
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2016 May 20;34(5):346-51. doi: 10.3760/cma.j.issn.1001-9391.2016.05.008.
6
Larvicidal activity of natural and modified triterpenoids against Aedes aegypti (Diptera: Culicidae).天然及改性三萜类化合物对埃及伊蚊（双翅目：蚊科）的杀幼虫活性
Pest Manag Sci. 2016 Oct;72(10):1883-7. doi: 10.1002/ps.4221. Epub 2016 Feb 17.
7
Acetylcholinesterase-independent protective effects of huperzine A against iron overload-induced oxidative damage and aberrant iron metabolism signaling in rat cortical neurons.石杉碱甲对大鼠皮质神经元铁过载诱导的氧化损伤及异常铁代谢信号传导的非乙酰胆碱酯酶依赖性保护作用。
Acta Pharmacol Sin. 2016 Nov;37(11):1391-1400. doi: 10.1038/aps.2016.78. Epub 2016 Aug 8.
8
A rifampicin-resistant (rpoB) mutation in Pseudomonas protegens Pf-5 strain leads to improved antifungal activity and elevated production of secondary metabolites.恶臭假单胞菌Pf-5菌株中的利福平抗性（rpoB）突变导致抗真菌活性提高和次级代谢产物产量增加。
Res Microbiol. 2016 Oct;167(8):625-629. doi: 10.1016/j.resmic.2016.05.001. Epub 2016 May 18.
9
Endoplasmic reticulum stress as a novel cellular response to di (2-ethylhexyl) phthalate exposure.内质网应激作为一种对邻苯二甲酸二（2-乙基己基）酯暴露的新型细胞反应。
Toxicol In Vitro. 2015 Dec 25;30(1 Pt B):281-7. doi: 10.1016/j.tiv.2015.10.009. Epub 2015 Oct 26.
10
Insights into the binding sites of sulforaphane on insulin studied by electrospray ionization mass spectrometry.通过电喷雾电离质谱法研究萝卜硫素与胰岛素结合位点的见解。
Rapid Commun Mass Spectrom. 2015 Jun 30;29(12):1155-64. doi: 10.1002/rcm.7212.