Galimberti R L, Villalba I, Galarza S, Raimondi A, Flores V
Rev Infect Dis. 1987 Jan-Feb;9 Suppl 1:S134-8. doi: 10.1093/clinids/9.supplement_1.s134.
Twenty-eight patients with pityriasis versicolor were treated orally with 200 mg of itraconazole per day in an open, randomized comparison of five-day and seven-day treatment regimens. The morphologic changes in Malassezia furfur produced by treatment were confirmed by studies with transmission and scanning electron microscopy. The clinical results showed that seven days of treatment were more effective than five days. Transmission electron microscopy revealed cytopathic changes in the fungus at the end of treatment, intracellular necrosis being complete within seven to 28 days. Cell-surface alterations detected by scanning electron microscopy developed more slowly--maximal changes were observed 14 days after the beginning of treatment. One patient developed nausea during treatment; no other adverse effects were attributed to the drug.
28例花斑糠疹患者接受了一项开放、随机对照试验，比较每日口服200毫克伊曲康唑，为期5天和7天的治疗方案。通过透射电子显微镜和扫描电子显微镜研究证实了治疗对糠秕马拉色菌产生的形态学变化。临床结果显示，7天的治疗比5天更有效。透射电子显微镜显示治疗结束时真菌出现细胞病变，细胞内坏死在7至28天内完全形成。扫描电子显微镜检测到的细胞表面改变发展较慢，在治疗开始后14天观察到最大变化。一名患者在治疗期间出现恶心；未发现其他与该药物相关的不良反应。
