Delescluse J
Department of Dermatology, Clinic Cesar De Paepe, Brussels, Belgium.
J Am Acad Dermatol. 1990 Sep;23(3 Pt 2):551-4. doi: 10.1016/0190-9622(90)70252-d.
Itraconazole, a new orally active triazole antifungal, has been tested in patients with pityriasis versicolor. A number of studies have shown that itraconazole is effective for this mild fungal skin disease. The total dose required for effective treatment is 1000 mg, and it has been given as 200 mg for 5 days or 7 days. The organisms disappear slowly from the skin, even when dead, and the results should be assessed clinically and mycologically at around 3 to 4 weeks after treatment. Numerous studies have shown that itraconazole is superior to placebo and as effective as selenium sulfide, clotrimazole, and ciclopirox olamine. It is also better tolerated by patients than selenium sulfide.
伊曲康唑是一种新型口服活性三唑类抗真菌药，已在花斑癣患者中进行了试验。多项研究表明，伊曲康唑对这种轻度真菌性皮肤病有效。有效治疗所需的总剂量为1000毫克，给药方式为每日200毫克，共5天或7天。即使真菌已死亡，它们仍会缓慢地从皮肤上消失，因此应在治疗后约3至4周进行临床和真菌学评估。大量研究表明，伊曲康唑优于安慰剂，且与硫化硒、克霉唑和环吡酮胺效果相当。患者对它的耐受性也优于硫化硒。
