Children and Adolescents Macrovascular Reactivity Level and Dynamics, But Not the Microvascular Response, is Associated with Body Mass Index and Arterial Stiffness Levels.

INTRODUCTION

The existing evidence indicates that primary prevention of atherosclerotic disease should begin in childhood. Detection of children and adolescents at risk for atherosclerosis may allow early intervention to decrease the atherosclerotic process, thereby preventing or delaying cardiovascular disease. Vascular reactivity (VR) is altered even by early atherosclerosis. Obesity is a main cardiovascular risk factor (CVRF) observed in childhood. If childhood obesity associates impaired macro and/or micro VR is controversial.

AIMS

To characterize macro and micro VR analyzing the stimulus and vascular response temporal profiles in children and adolescents considering their body mass index (BMI); and to assess potential associations between subjects' characteristics and the hyperemic stimulus and/or VR.

METHODS

Healthy subjects (n = 99, age 5-17 years, female 46%) were included. Considering the BMI, normal, overweight and obese groups were defined. CVRF exposure was assessed. Brachial flow-mediated dilation and reactive hyperemia, associated with transient ischemia (forearm cuff-inflation) were evaluated. Diameter, flow velocities, resistive indexes and shear-stress were determined before, during and after cuff-release. Complimentary VR indexes were computed. Aortic stiffness and aortic and brachial blood pressure were determined.

RESULTS

Obese showed the lowest and slowest macrovascular response (p < 0.05). Micro VR was not associated with obesity. Higher aortic stiffness levels were associated with slower macrovascular responses (p < 0.05).

CONCLUSION

Childhood obesity associates not only reduced, but also slowed macrovascular reactivity. Microvascular response to transient ischemia is preserved in obese children. Macro and microvascular responses would be non-associated phenomena in childhood. During childhood, VR dynamics would depend on the arterial stiffness.