Adrian T, Schäfer G, Cooney M K, Fox J P, Wigand R
Department of Virology, University of the Saarland, FRG.
Epidemiol Infect. 1988 Dec;101(3):503-9. doi: 10.1017/s0950268800029393.
Isolates of adenovirus types 1 and 2, obtained from 11 infants with prolonged faecal excretion (up to 515 days), were compared by DNA restriction analysis with seven standard endonucleases which recognize hexanucleotides and two additional endonucleases which recognize tetranucleotides. In all instances identical genome types were identified in isolates obtained early and late after infection. Our interpretation of these data is that a chronic persistent infection occurred in these children, and not a reinfection with the same serotype.
从11名粪便长期排出（长达515天）的婴儿中分离出1型和2型腺病毒，通过DNA限制性分析，将其与7种识别六核苷酸的标准核酸内切酶和另外2种识别四核苷酸的核酸内切酶进行比较。在所有情况下，感染早期和晚期获得的分离株中均鉴定出相同的基因组类型。我们对这些数据的解释是，这些儿童发生了慢性持续性感染，而非同一血清型的再次感染。
