Fife K H, Ashley R, Corey L
J Clin Microbiol. 1985 Jan;21(1):20-3. doi: 10.1128/jcm.21.1.20-23.1985.
Several of the 41 types of human adenovirus have been divided into genome types based on aberrant restriction endonuclease digestion patterns of viral DNA. In the process of screening a large number of clinical adenovirus isolates by restriction endonuclease digestion of viral DNA, we have identified nine isolates from eight patients which were identified by neutralization as adenovirus type 1 or 2 but had aberrant cleavage patterns. Cleavage sites for the enzymes SmaI, EcoRI, HindIII, KpnI, and HpaI were mapped. The variants could be placed in six distinct groups based on cleavage patterns. The designation genome types 1a, 1b, 1c, 2b, 2c, and 2d are proposed for these isolates.
41种人类腺病毒中的几种已根据病毒DNA异常的限制性内切酶消化模式被划分为基因组类型。在通过病毒DNA的限制性内切酶消化筛选大量临床腺病毒分离株的过程中，我们从8名患者中鉴定出9株分离株，这些分离株经中和鉴定为1型或2型腺病毒，但具有异常的切割模式。绘制了SmaI、EcoRI、HindIII、KpnI和HpaI酶的切割位点。根据切割模式，这些变体可分为六个不同的组。建议将这些分离株命名为基因组类型1a、1b、1c、2b、2c和2d。
