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提取物对阿尔茨海默病的神经保护作用。

Neuroprotective Effect of Extract against Alzheimer's Disease.

作者信息

Liang Chen, Yuan Jian-Ping, Ding Tao, Yan Lv, Ling Lu, Zhou Xin-Fu, Zeng Yue-Qin

机构信息

Key Laboratory of Stem Cells and Regenerative Medicine, Institute of Molecular and Clinical Medicine, Kunming Medical University, Kunming, China.

Department of Pharmacy, First People's Hospital of Qujin, Qujin, China.

出版信息

Evid Based Complement Alternat Med. 2017;2017:3294586. doi: 10.1155/2017/3294586. Epub 2017 Apr 20.

DOI:10.1155/2017/3294586
PMID:28512499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5415668/
Abstract

Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway. is a traditional herbal medicine which contains high quantity phenols. In present study, we investigate the beneficial pharmacological actions of extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of A peptide were evaluated in vitro. After 9-month treatment, FDE exhibited multifunctional properties on A-related pathologies, which cleaned A deposits in the brain and decreased A burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PS1 transgenic mice and also promoted A fibrils disaggregation and inhibited neurotoxicity induced by A in SH-SY5Y cells. These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.

摘要

越来越多的证据表明，草药中含有的多酚类抗氧化剂在预防阿尔茨海默病（AD）中发挥着重要作用；神经保护作用背后的分子机制依赖于酚类物质对淀粉样蛋白聚集途径的不同影响。[草药名称]是一种含有大量酚类物质的传统草药。在本研究中，我们研究了[草药名称]提取物在APP/PS1转基因小鼠模型中的有益药理作用；同时，在体外评估了[草药名称]提取物对Aβ肽的纤维化和细胞毒性的影响。经过9个月的治疗，[草药名称]提取物在与Aβ相关的病理方面表现出多功能特性，它清除了大脑中的Aβ沉积物，降低了血浆中的Aβ负担，抑制了微出血，并减少了APP/PS1转基因小鼠中的反应性小胶质细胞，还促进了Aβ纤维的解聚，并抑制了SH-SY5Y细胞中Aβ诱导的神经毒性。这些结果突出表明，[草药名称]提取物是一种具有治疗AD潜力的AD型病理调节剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/d9aff472e7c8/ECAM2017-3294586.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/192e2cc0fa70/ECAM2017-3294586.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2090f98715c3/ECAM2017-3294586.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2100a82025ea/ECAM2017-3294586.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/44f6c5e4e46a/ECAM2017-3294586.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/e09a06d9afaf/ECAM2017-3294586.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/5d8a0b96d250/ECAM2017-3294586.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2b45989e6eba/ECAM2017-3294586.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/d9aff472e7c8/ECAM2017-3294586.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/192e2cc0fa70/ECAM2017-3294586.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2090f98715c3/ECAM2017-3294586.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2100a82025ea/ECAM2017-3294586.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/44f6c5e4e46a/ECAM2017-3294586.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/e09a06d9afaf/ECAM2017-3294586.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/5d8a0b96d250/ECAM2017-3294586.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/2b45989e6eba/ECAM2017-3294586.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1f4/5415668/d9aff472e7c8/ECAM2017-3294586.008.jpg

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