Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China.
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Molecules. 2017 Nov 18;22(11):1998. doi: 10.3390/molecules22111998.
This study aimed to identify a new biological activity of the widely distributed species . Four extracts (ethyl acetate (EA), petroleum ether (P), ethanol (E), and water (W)) were explored for their anti-neuraminidase (NA) activity. A total of 32 compounds were identified using UHPLC-Q-Exactive Orbitrap HRMS in the EA extract, which had the best NA inhibitory effects. We used the docking data for supporting compounds' anti-neuraminidase activity. Among them, five compounds including one flavonoid, three organic acids, and one glucoside were discovered for the first time in . Docking studies and NA activity assay revealed the remarkable NA inhibitory activity of eight components in EA extract, especially rutin, hesperidin, procyanidin B₂, and quercitrin. Therefore, could be used to develop anti-influenza drugs.
本研究旨在确定广泛分布的物种的新生物活性。探索了四种提取物（乙酸乙酯（EA）、石油醚（P）、乙醇（E）和水（W））的抗神经氨酸酶（NA）活性。在 EA 提取物中使用 UHPLC-Q-Exactive Orbitrap HRMS 鉴定了 32 种化合物，EA 提取物具有最佳的 NA 抑制作用。我们使用对接数据来支持化合物的抗神经氨酸酶活性。其中，五种化合物包括一种类黄酮、三种有机酸和一种糖苷，首次在中发现。对接研究和 NA 活性测定显示，EA 提取物中八种成分具有显著的 NA 抑制活性，特别是芦丁、橙皮苷、原花青素 B₂和槲皮素。因此，可用于开发抗流感药物。
