Department of Radiation Oncology, University of Colorado School of Medicine, 1665 Aurora Court, Suite 1032, Mail stop, F-706, Aurora, CO, 80045, USA.
Med Phys. 2017 Aug;44(8):3952-3964. doi: 10.1002/mp.12346. Epub 2017 Jun 16.
High fraction of scattered radiation in cone-beam CT (CBCT) imaging degrades CT number accuracy and visualization of low contrast objects. To suppress scatter in CBCT projections, we developed a focused, two-dimensional antiscatter grid (2DASG) prototype. In this work, we report on the primary and scatter transmission characteristics of the 2DASG prototype aimed for linac mounted, offset detector geometry CBCT systems in radiation therapy, and compared its performance to a conventional one-dimensional ASG (1DASG).
The 2DASG is an array of through-holes separated by 0.1 mm septa that was fabricated from tungsten using additive manufacturing techniques. Through-holes' focusing geometry was designed for offset detector CBCT in Varian TrueBeam system. Two types of ASGs were evaluated: (a) a conventional 1DASG with a grid ratio of 10, (b) the 2DASG prototype with a grid ratio of 8.2. To assess the scatter suppression performance of both ASGs, Scatter-to-primary ratio (SPR) and scatter transmission fraction (Ts) were measured using the beam stop method. Scatter and primary intensities were modulated by varying the phantom thickness between 10 and 40 cm. Additionally, the effect of air gap and bow tie (BT) filter on SPR and Ts were evaluated. Average primary transmission fraction (T ) and pixel specific primary transmission were also measured for both ASGs. To assess the effect of transmission characteristics on projection image signal-to-noise ratio (SNR), SNR improvement factor was calculated. Improvement in contrast to noise ratio (CNR) was demonstrated using a low contrast object.
In comparison to 1DASG, 2DASG reduced SPRs by a factor of 3 to 6 across the range of phantom setups investigated. Ts values for 1D and 2DASGs were in the range of 21 to 29%, and 5 to 14% respectively. 2DASG continued to provide lower SPR and Ts at increased air gap and with BT filter. Tp of 1D and 2DASGs were 70.6% and 84.7% respectively. Due to the septal shadow of the 2DASG, its pixel specific primary transmission values varied between 32.5% and 99.1%. With respect to 1DASG, 2DASG provided up to factor of 1.7 more improvement in SNR across the SPR range investigated. Moreover, 2DASG provided improved visualization of low contrast objects with respect to 1DASG and NOASG setups.
When compared to a conventional 1DASG, 2DASG prototype provided noticeably lower SPR and Ts values, indicating its superior scatter suppression performance. 2DASG also provided 19% higher average primary transmission that was attributed to the absence of interseptal spacers and optimized grid geometry. Our results indicate that the combined effect of lower scatter and higher primary transmission provided by 2DASG may potentially translate into more accurate CT numbers and improved contrast resolution in CBCT images.
锥形束 CT(CBCT)成像中散射辐射的高分数会降低 CT 数的准确性和低对比度物体的可视化效果。为了抑制 CBCT 投影中的散射,我们开发了一种聚焦的二维散射抑制栅格(2DASG)原型。在这项工作中,我们报告了 2DASG 原型的主要和散射传输特性,该原型旨在用于放射治疗中的直线加速器安装的、偏移探测器几何结构的 CBCT 系统,并将其性能与传统的一维散射抑制栅格(1DASG)进行了比较。
2DASG 是由钨采用增材制造技术制造的、由 0.1 毫米间隔的贯穿孔组成的阵列。贯穿孔的聚焦几何形状是为瓦里安 TrueBeam 系统中的偏移探测器 CBCT 设计的。评估了两种类型的 ASG:(a)网格比为 10 的传统 1DASG,(b)网格比为 8.2 的 2DASG 原型。为了评估两种 ASG 的散射抑制性能,使用束流阻挡法测量了散射与原始射线的比例(SPR)和散射传输分数(Ts)。通过在 10 到 40 厘米之间改变体模厚度来调制散射和原始射线的强度。此外,还评估了空气间隙和蝴蝶结(BT)滤波器对 SPR 和 Ts 的影响。还测量了两种 ASG 的平均原始射线传输分数(Tp)和像素特定的原始射线传输分数。为了评估传输特性对投影图像信噪比(SNR)的影响,计算了 SNR 改善因子。使用低对比度物体演示了对比度到噪声比(CNR)的改善。
与 1DASG 相比,2DASG 在研究的所有体模设置中降低了 3 到 6 倍的 SPR。1D 和 2DASG 的 Ts 值分别在 21%到 29%和 5%到 14%之间。在增加空气间隙和使用 BT 滤波器时,2DASG 仍能提供更低的 SPR 和 Ts。1D 和 2DASG 的 Tp 分别为 70.6%和 84.7%。由于 2DASG 的隔板阴影,其像素特定的原始射线传输值在 32.5%到 99.1%之间变化。与 1DASG 相比,2DASG 在研究的 SPR 范围内提供了高达 1.7 倍的 SNR 改善。此外,2DASG 提供了比 1DASG 和无散射抑制栅格(NOASG)设置更好的低对比度物体可视化效果。
与传统的 1DASG 相比,2DASG 原型提供了明显更低的 SPR 和 Ts 值,表明其具有更好的散射抑制性能。2DASG 还提供了 19%的更高平均原始射线传输,这归因于没有隔板间隔物和优化的栅格几何形状。我们的结果表明,2DASG 提供的更低散射和更高原始射线传输的综合效果可能会在 CBCT 图像中转化为更准确的 CT 数和更好的对比度分辨率。