Cao Ling-Zhi, Peng Xiao-Dong, Xie Jian-Ping, Yang Fan-Hui, Wen Hu-Ling, Li Suping
Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong Key Laboratory of Chronobiology of the Health Ministry, Basic and Forensic School, Sichuan University, Chengdu, Sichuan, China.
Medicine (Baltimore). 2017 May;96(20):e6734. doi: 10.1097/MD.0000000000006734.
Thyroid cancer (TC) is the most common malignancy of the endocrine system. The relationship between iodine intake and TC risk is controversial always. We aim to figure out the relationship between iodine intake and TC using meta-analysis. Literature research in MEDLINE, Embase, China National Knowledge Infrastructure, and China BioMedicine was performed up to April 2016, searched for relevant case-control and cohort studies. The effect of iodine consumption on the risk of TC was assessed using the pooled odds ratio (OR) and 95% confidence interval (CI). The meta-analysis included 8 case-control studies (n = 4974; 2213 cases; 2761 controls). More than adequate or excess iodine intake (>300 μg/d) decreased the risk of TC (OR 0.74, 95% CI 0.60, 0.92). High consumption of saltwater fish or shellfish decreased the risk of TC (OR 0.72, 95% CI 0.55, 0.95; OR 0.70, 95% CI 0.52, 0.96; respectively). A higher intake of dietary iodine was as a protective factor for TC. However, the available data are very limited and more studies are required.
甲状腺癌（TC）是内分泌系统最常见的恶性肿瘤。碘摄入量与TC风险之间的关系一直存在争议。我们旨在通过荟萃分析来明确碘摄入量与TC之间的关系。截至2016年4月，我们在MEDLINE、Embase、中国知网和中国生物医学数据库中进行了文献研究，搜索相关的病例对照研究和队列研究。使用合并比值比（OR）和95%置信区间（CI）评估碘摄入对TC风险的影响。该荟萃分析纳入了8项病例对照研究（n = 4974；2213例病例；2761例对照）。碘摄入量充足以上或过量（>300μg/d）可降低TC风险（OR 0.74，95%CI 0.60，0.92）。大量食用海水鱼或贝类可降低TC风险（分别为OR 0.72，95%CI 0.55，0.95；OR 0.70, 95%CI 0.52, 0.96）。较高的膳食碘摄入量是TC的一个保护因素。然而，现有数据非常有限，还需要更多的研究。
