Olenchock Benjamin A, Rathmell Jeffrey C, Vander Heiden Matthew G
Division of Cardiovascular Medicine, Department of Medicine, The Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232-2363, USA.
Immunity. 2017 May 16;46(5):703-713. doi: 10.1016/j.immuni.2017.04.013.
The metabolism of immune cells affects their function and influences host immunity. This review explores how immune cell metabolic phenotypes reflect biochemical dependencies and highlights evidence that both the metabolic state of immune cells and nutrient availability can alter immune responses. The central importance of oxygen, energetics, and redox homeostasis in immune cell metabolism, and how these factors are reflected in different metabolic phenotypes, is also discussed. Linking immune cell metabolic phenotype to effector functions is important to understand how altering metabolism can impact the way in which immune cells meet their metabolic demands and affect the immune response in various disease contexts.
免疫细胞的代谢会影响其功能，并对宿主免疫产生影响。本综述探讨了免疫细胞代谢表型如何反映生化依赖性，并着重介绍了免疫细胞代谢状态和营养物质可用性均可改变免疫反应的相关证据。文中还讨论了氧气、能量学和氧化还原稳态在免疫细胞代谢中的核心重要性，以及这些因素如何在不同的代谢表型中体现。将免疫细胞代谢表型与效应功能联系起来，对于理解改变代谢如何影响免疫细胞满足其代谢需求的方式以及在各种疾病背景下影响免疫反应至关重要。
