* College of Veterinary Medicine, Seoul National University, Gwanak-ro 1-gil, Gwanak-gu, Seoul 08826, Republic of Korea.
† Graduate Group of Tumor Biology, Seoul National University, Daehangno 103-gil, Jongno-gu, Seoul 03080, Republic of Korea.
Am J Chin Med. 2017;45(4):813-832. doi: 10.1142/S0192415X17500434. Epub 2017 May 18.
This study used an integrated approach to investigate the effects of Gymnema sylvestre (GS) extract as a functional dietary supplement with a high-fat diet. This approach examined insulin resistance, the dysfunction of adipose tissue, and liver steatosis. Male C57BL/6J mice were fed a normal chow or high-fat diet (HFD) for the acute and chronic study, in addition to GS in different doses (100, 250 and 500[Formula: see text]mg/kg body weight). Their body composition changes, serum lipid and glucose parameters, adipose and liver tissue histology, and gene expression were measured. It was found that GS significantly suppressed the increase of body weight, serum levels of lipid, insulin and leptin, and adipose tissue, and liver inflammation. GS also demonstrated hypoglycemic effects due to the amylase inhibition activity. Our results support the existence of a relationship between the HFD induced insulin resistance, adipose dysfunction and liver steatosis. In conclusion, GS works as a functional dietary supplement with preventative effects against metabolic disorder.
本研究采用综合方法研究匙羹藤（GS）提取物作为一种功能性膳食补充剂对高脂肪饮食的影响。该方法研究了胰岛素抵抗、脂肪组织功能障碍和肝脂肪变性。雄性 C57BL/6J 小鼠分别给予正常饲料或高脂肪饲料（HFD）进行急性和慢性研究，并给予不同剂量（100、250 和 500[Formula: see text]mg/kg 体重）的 GS。测量了它们的身体成分变化、血清脂质和葡萄糖参数、脂肪和肝脏组织学以及基因表达。结果表明，GS 可显著抑制体重、血清脂质、胰岛素和瘦素水平以及脂肪和肝脏炎症的增加。GS 还通过抑制淀粉酶活性显示出降血糖作用。我们的研究结果支持 HFD 诱导的胰岛素抵抗、脂肪组织功能障碍和肝脂肪变性之间存在关联。总之，GS 作为一种功能性膳食补充剂，具有预防代谢紊乱的作用。
