Akbay Esin, Özenirler Çiğdem, Çelemli Ömür Gençay, Durukan Ahmet Baris, Onur Mehmet Ali, Sorkun Kadriye
Department of Biology, Faculty of Science, Hacettepe University, Ankara, Turkey.
Department of Cardiovascular Surgery, Medical Park, Private Uşak Hospital, Uşak, Turkey.
Kardiochir Torakochirurgia Pol. 2017 Mar;14(1):43-46. doi: 10.5114/kitp.2017.66929. Epub 2017 Mar 31.
Warfarin is commonly used to avoid thromboembolism, predominantly for cardiovascular pathologies. However, the consumption of several herbal products is not permitted during its use due to the associated interactions. Propolis is a popular phytotherapy product made by honey bees. The use of propolis has been dramatically increasing in recent times.
To evaluate the possible interactions between propolis and warfarin in a mouse model with determination of the international normalized ratio (INR) values.
CD-1 mice were employed in the experimental model. The mice were warfarinized, and propolis was administered simultaneously. The INR values were obtained. All animals were sacrificed at the end of the study.
The baseline INR value was 0.8 ±0.1. After 72 h, the INR value increased as expected. The INR value was 7.28 ±1.08 in the control group and 5.8 ±2.88 in the propolis group. At the end of the study, the INR value was 1.3 ±0.37. Propolis interacted with warfarin and caused a decrease in the INR value.
Propolis interactions, especially with warfarin, should be kept in mind and further studied. Healthcare specialists should be aware of this possible interaction between warfarin and propolis and inform patients about it.
华法林常用于预防血栓栓塞，主要用于心血管疾病。然而，在使用华法林期间，由于存在相互作用，不允许同时服用几种草药产品。蜂胶是蜜蜂制作的一种受欢迎的植物疗法产品。近年来，蜂胶的使用量急剧增加。
在小鼠模型中评估蜂胶与华法林之间可能的相互作用，并测定国际标准化比值（INR）。
实验模型采用CD-1小鼠。对小鼠进行华法林化处理，并同时给予蜂胶。获取INR值。研究结束时处死所有动物。
基线INR值为0.8±0.1。72小时后，INR值如预期升高。对照组INR值为7.28±1.08，蜂胶组为5.8±2.88。研究结束时，INR值为1.3±0.37。蜂胶与华法林相互作用，导致INR值降低。
应牢记蜂胶的相互作用，尤其是与华法林的相互作用，并进一步研究。医疗保健专家应意识到华法林与蜂胶之间这种可能的相互作用，并告知患者。
