Li Chun-Xia, Zhang Xiaodong
Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, GA, 30329, USA.
Quant Imaging Med Surg. 2017 Apr;7(2):267-275. doi: 10.21037/qims.2017.04.03.
With the advent of parallel imaging MRI techniques, whole-body MRI is being increasingly used in clinical diagnosis. However, its application in preclinical research using large animals remains very limited. In the present study, the whole-body MRI techniques for adult macaque monkeys were explored using a conventional clinic 3T scanner. The T1, T2 anatomical images, and MR angiography of adult macaque whole bodies were illustrated. The preliminary results suggest whole-body MRI can be a robust tool to examine multiple organs of non-human primate (NHP) models from head to toe non-invasively and simultaneously using a conventional clinical setting. As NHPs are intensely used in biomedical research such as HIV/AIDS and vaccine discovery, whole body MRI techniques can have a wide range of applications in translational research using NHPs.
随着并行成像磁共振成像（MRI）技术的出现，全身MRI在临床诊断中的应用越来越广泛。然而，其在使用大型动物的临床前研究中的应用仍然非常有限。在本研究中，我们使用传统的临床3T扫描仪探索了成年猕猴的全身MRI技术。展示了成年猕猴全身的T1、T2解剖图像以及磁共振血管造影。初步结果表明，全身MRI可以成为一种强大的工具，能够在传统临床环境中，从头部到脚趾非侵入性地同时检查非人类灵长类动物（NHP）模型的多个器官。由于NHP在诸如艾滋病毒/艾滋病和疫苗研发等生物医学研究中被大量使用，全身MRI技术在使用NHP进行转化研究中可具有广泛的应用。
