Isa M, Iqbal K, Afzal M, Buzdar S, Chow J
The Islamia University of Bahawalpur.
Shaukat Khanum Cancer Hospital and Research Center.
Med Phys. 2012 Jul;39(7Part3):4636. doi: 10.1118/1.4740168.
The aim of this study is to compare the dosimetry of the physical wedge (PW) and enhanced dynamic wedge (EDW) in radiotherapy of rectal cancer. Two wedge angles of 45° and 60° were used in the comparison due to the size of the pelvis contour. 6 and 15 MV photon beams produced from a Varian 21 CD linear accelerator were used. Thirty rectum patients were investigated using the three-field technique. Treatment plans using the PWs and EDWs were created using the Eclipse treatment planning system. Monitor units, plan normalization value, maximum and minimum doses in the planning target volume (PTV), dose conformity index, dose homogeneity index and uniformity index were determined for each treatment plan. The average dose coverage for the PTV with EDW and PW plans were compared. The PTV received prescription doses of 100.9±0.74%, 101.01±1.63% for the EDW (45°, 60°) compared to 101.2±1.65%, 101.3±1.33% for the PW (45°, 60°). Homogeneity indices were (0.11±0.02%, 0.11±0.05%) for the EDW (45°, 60°), and (0.15±0.1%, 0.16±0.11%) for the PW (45°, 60°), respectively. The EDW at 45° had better target coverage with higher conformity index value of 0.98 ± 0.01 compared to the other wedges. A statistically significant (p < 0.01) change in plan normalization values and fewer monitor units were found using the EDW at 45°. We conclude that the EDW at 45° results in an improvement to the plan evaluation parameters presented and thus increases dose efficacy for radiotherapy of rectal cancer.
本研究旨在比较物理楔形板(PW)和增强动态楔形板(EDW)在直肠癌放射治疗中的剂量学。由于骨盆轮廓的大小,在比较中使用了45°和60°两个楔形角。使用瓦里安21CD直线加速器产生的6和15MV光子束。采用三野技术对30例直肠癌患者进行研究。使用Eclipse治疗计划系统创建了使用PW和EDW的治疗计划。确定每个治疗计划的监测单位、计划归一化值、计划靶区(PTV)的最大和最小剂量、剂量适形指数、剂量均匀性指数和均匀性指数。比较了EDW和PW计划对PTV的平均剂量覆盖情况。与PW(45°,60°)的101.2±1.65%、101.3±1.33%相比,EDW(45°,60°)的PTV接受的处方剂量为100.9±0.74%、101.01±1.63%。EDW(45°,60°)的均匀性指数分别为(0.11±0.02%,0.11±0.05%),PW(45°,60°)的均匀性指数分别为(0.