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使用物理楔形板和增强动态楔形板进行乳腺放射治疗计划时治疗计划的剂量学比较

Dosimetric Comparison of Treatment Plans Using Physical Wedge and Enhanced Dynamic Wedge for the Planning of Breast Radiotherapy.

作者信息

Gopalakrishnan Zhenia, Nair Raghuram K, Raghukumar P, Sarin B

机构信息

Division of Radiation Physics, Regional Cancer Centre, Trivandrum, Kerala, India.

出版信息

J Med Phys. 2018 Jan-Mar;43(1):46-51. doi: 10.4103/jmp.JMP_40_17.

Abstract

The aim of this study is to compare the physical wedge (PW) with enhanced dynamic wedge (EDW) to determine the difference in the dose distribution affecting the treated breast and the contralateral breast, lungs, heart, esophagus, spine, and surrounding skin in the radiotherapy of breast cancer. Computed tomography (CT) data sets of 30 breast cancer patients were selected from the database for the study. The treatment plans which were executed with PW were re-planned with EDW without changing the beam parameters. Keeping the wedge angles same, the analytic anisotropic algorithm (AAA) with heterogeneity correction was used for dose calculation in all plans. The prescription was 50 Gy in 25 fractions. The dose- volume histogram (DVH) of the planning target volume (PTV) and critical structures of both PW and EDW plans were analyzed. The analysis showed that the maximum dose within the target volume is higher in EDW plan compared to PW plan. However the PTV conformity index (CI) remained the same in both plans. For all the critical structures, the EDW technique offered less dose compared to PW technique. The effect of volume of the contralateral breast on the dose to contralateral breast and the effect of volume of PTV breast for patients with carcinoma left breast on the dose to heart were studied and analyzed for the two wedges. No correlation between volumes and dose parameters was found for the two techniques. The number of monitor units to deliver a particular dose with EDW field is less than that of PW field due to change in wedge factor. As EDW produces less scattered dose to structures outside the treatment field, the risk of a second malignancy can be reduced with this technique.

摘要

本研究的目的是比较物理楔形板(PW)与动态增强楔形板(EDW),以确定在乳腺癌放射治疗中,影响治疗侧乳房及对侧乳房、肺、心脏、食管、脊柱和周围皮肤的剂量分布差异。从数据库中选取30例乳腺癌患者的计算机断层扫描(CT)数据集用于本研究。对采用PW执行的治疗计划,在不改变射束参数的情况下,用EDW重新规划。保持楔形角相同,在所有计划中均使用具有不均匀性校正的解析各向异性算法(AAA)进行剂量计算。处方剂量为50 Gy,分25次给予。分析了PW和EDW计划的计划靶区(PTV)及关键结构的剂量体积直方图(DVH)。分析表明,与PW计划相比,EDW计划靶区内的最大剂量更高。然而,两个计划中PTV的适形指数(CI)保持不变。对于所有关键结构,与PW技术相比,EDW技术提供的剂量更少。研究并分析了两个楔形板中对侧乳房体积对其剂量的影响,以及左乳癌患者PTV乳房体积对心脏剂量的影响。两种技术在体积与剂量参数之间均未发现相关性。由于楔形因子的变化,使用EDW射野给予特定剂量时的监测单位数少于PW射野。由于EDW对治疗野外结构产生的散射剂量较少,采用该技术可降低二次恶性肿瘤的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db25/5879823/8b202a6d3cfb/JMP-43-46-g002.jpg

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