细胞膜包覆纳米粒子的生物界面与应用
Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles.
作者信息
Kroll Ashley V, Fang Ronnie H, Zhang Liangfang
机构信息
Department of NanoEngineering and Moores Cancer Center, University of California , San Diego, La Jolla, California 92093, United States.
出版信息
Bioconjug Chem. 2017 Jan 18;28(1):23-32. doi: 10.1021/acs.bioconjchem.6b00569. Epub 2016 Nov 16.
Abstract
The cell membrane-coated nanoparticle is a biomimetic platform consisting of a nanoparticulate core coated with membrane derived from a cell, such as a red blood cell, platelet, or cancer cell. The cell membrane "disguise" allows the particles to be perceived by the body as the source cell by interacting with its surroundings using the translocated surface membrane components. The newly bestowed characteristics of the membrane-coated nanoparticle can be utilized for biological interfacing in the body, providing natural solutions to many biomedical issues. This Review will cover the interactions of these cell membrane-coated nanoparticles and their applications within three biomedical areas of interest, including (i) drug delivery, (ii) detoxification, and (iii) immune modulation.
摘要
细胞膜包被纳米颗粒是一种仿生平台，由包裹着源自细胞（如红细胞、血小板或癌细胞）的膜的纳米颗粒核心组成。细胞膜“伪装”使颗粒通过利用易位的表面膜成分与周围环境相互作用，从而被机体视为源细胞。细胞膜包被纳米颗粒新赋予的特性可用于体内生物界面，为许多生物医学问题提供天然解决方案。本综述将涵盖这些细胞膜包被纳米颗粒的相互作用及其在三个感兴趣的生物医学领域中的应用，包括（i）药物递送、（ii）解毒和（iii）免疫调节。
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