神经退行性和神经炎症途径中的过氧化物酶体增殖物激活受体
PPARs in Neurodegenerative and Neuroinflammatory Pathways.
作者信息
Benedetti E, Cristiano L, Antonosante A, d'Angelo M, D'Angelo B, Selli S, Castelli V, Ippoliti R, Giordano A, Cimini A
机构信息
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
出版信息
Curr Alzheimer Res. 2018 Feb 22;15(4):336-344. doi: 10.2174/1567205014666170517150037.
BACKGROUND
PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.
METHODS
In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.
RESULTS
In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.
CONCLUSION
Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.
背景
过氧化物酶体增殖物激活受体（PPARs）是由膳食脂质或其代谢产物（主要是脂肪酸和类花生酸）激活的脂质传感器，由于大脑脂质含量非常高且在体内具有较高的能量代谢，因此在中枢神经系统生物学中发挥关键作用。
方法
在神经退行性疾病中，除了代谢损害外，还观察到神经炎症，并且PPARs也与炎症过程密切相关。多项研究揭示了先天免疫反应与组织代谢之间的复杂关系。
结果
在大脑中，在病理状态下，代谢状态会发生改变，特别是涉及葡萄糖利用和生成，这种情况通常与代谢变化有关。
结论
考虑到PPARs在大脑中的高表达，本综述将聚焦于这些转录因子在中枢神经系统疾病中的作用。
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