Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Int J Mol Sci. 2018 Jun 26;19(7):1869. doi: 10.3390/ijms19071869.
Peroxisome proliferator activated receptors (PPARs) are a class of ligand-activated transcription factors, belonging to the superfamily of receptors for steroid and thyroid hormones, retinoids, and vitamin D. PPARs control the expression of several genes connected with carbohydrate and lipid metabolism, and it has been demonstrated that PPARs play important roles in determining neural stem cell (NSC) fate. Lipogenesis and aerobic glycolysis support the rapid proliferation during neurogenesis, and specific roles for PPARs in the control of different phases of neurogenesis have been demonstrated. Understanding the changes in metabolism during neuronal differentiation is important in the context of stem cell research, neurodegenerative diseases, and regenerative medicine. In this review, we will discuss pivotal evidence that supports the role of PPARs in energy metabolism alterations during neuronal maturation and neurodegenerative disorders.
过氧化物酶体增殖物激活受体 (PPARs) 是一类配体激活的转录因子，属于甾体和甲状腺激素、视黄醇和维生素 D 的受体超家族。PPARs 控制与碳水化合物和脂质代谢相关的几个基因的表达，已经证明 PPARs 在决定神经干细胞 (NSC) 命运方面发挥着重要作用。脂肪生成和有氧糖酵解支持神经发生过程中的快速增殖，并且已经证明 PPARs 在控制神经发生的不同阶段中具有特定作用。了解神经元分化过程中的代谢变化对于干细胞研究、神经退行性疾病和再生医学具有重要意义。在这篇综述中，我们将讨论支持 PPARs 在神经元成熟和神经退行性疾病期间能量代谢改变中发挥作用的关键证据。
