Zhang Yu, He An Qi, Li Lin, Chen Wei, Liu Zhen Guo
Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kong jiang Road, Shanghai, 200092, People's Republic of China.
BMC Neurol. 2017 May 18;17(1):98. doi: 10.1186/s12883-017-0874-6.
Impulse control and related disorders (ICRDs) are clinically complications in Parkinson's disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to explore the prevalence and the clinical profile of ICRDs in Chinese patients with PD.
142 Chinese PD patients were consecutively enrolled. The symptoms of ICRDs were assessed with the Questionnaire for Impulsive-Compulsive Disorders. The clinical characteristics of patients with ICRDs and without ICRDs were compared.
ICRDs were present in 31% of our patients. The most common ICRDs were compulsive medication use (11.3%) and punding (9.2%); the least frequent were walkabout (1.4%). Variables independently associated with ICRDs were earlier onset of the disease (≤55 years), severe cognitive impairment (MMSE 10-20), the dose of dopamine agonist (>1 mg/d) and dyskinesia.
ICRDs was commonly found in Chinese PD patients. Earlier onset of the disease, the dose of dopamine agonist, severe cognitive impairment and dyskinesia are independent factors associated with ICRDs. Our results will be benefit for clinicians to assess the risk of developing ICRDs before delivering dopaminergic medication.
冲动控制及相关障碍（ICRDs）是帕金森病（PD）的临床并发症。然而，关于中国PD患者中ICRDs临床特征的报道较少。我们旨在探讨中国PD患者中ICRDs的患病率及临床特征。
连续纳入142例中国PD患者。使用冲动控制障碍问卷评估ICRDs症状。比较有ICRDs和无ICRDs患者的临床特征。
我们的患者中有31%存在ICRDs。最常见的ICRDs是强迫性用药（11.3%）和刻板动作（9.2%）；最不常见的是徘徊症（1.4%）。与ICRDs独立相关的变量包括疾病早发（≤55岁）、严重认知障碍（简易精神状态检查表评分为10 - 20）、多巴胺激动剂剂量（>1mg/d）和异动症。
ICRDs在中国PD患者中普遍存在。疾病早发、多巴胺激动剂剂量、严重认知障碍和异动症是与ICRDs相关的独立因素。我们的结果将有助于临床医生在给予多巴胺能药物治疗前评估发生ICRDs的风险。
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