Magurano Fabio, Baggieri Melissa, Filia Antonietta, Del Manso Martina, Lazzarotto Tiziana, Amendola Antonella, D'Agaro Pierlanfranco, Chironna Maria, Ansaldi Filippo, Iannazzo Stefania, Bucci Paola, Marchi Antonella, Nicoletti Loredana
National Reference Laboratory for Measles and Rubella, Department of Infectious Diseases, National Institute of Health, Rome, Italy.
Department of Infectious Diseases, National Institute of Health, Rome, Italy.
Virus Res. 2017 May 15;236:24-29. doi: 10.1016/j.virusres.2017.05.009.
In accordance with the goal of the World Health Organization Regional Office for Europe, the Italian National Measles and Rubella Elimination Plan aimed to interrupt indigenous measles transmission in Italy by the end of 2015. However, from 2013 to 2015, Italy experienced high measles burden with 4902 measles cases (49.3% laboratory-confirmed) reported to the enhanced measles surveillance system (cumulative incidence in the triennium reference period: 2.4/100,000 population). The measles elimination goal was not reached. Laboratory surveillance of measles circulating genotypes is performed by the Measles and Rubella National Reference Laboratory (NRL) at the Italian National Institute of Health (Istituto Superiore di Sanità - ISS), in Rome. Samples received from 1 January 2013-31 December 2015 were analysed. Those positive for measles genome by molecular tests were sequenced and phylogenetically analysed. Phylogenetic analysis performed by NRL identified that genotypes D4 and D8 were endemic and co-circulated in 2011-2013: study results show that genotype D4 disappeared during 2013. Sporadic cases were associated to genotype B3 during 2011-2013, which became endemic in Italy during 2014 and co-circulated with D8 until 2015. Sporadic cases were found belonging to genotypes D9 and H1 all over the period in exam. Similar trend has been observed in European WHO Region.
根据世界卫生组织欧洲区域办事处的目标，意大利国家麻疹和风疹消除计划旨在到2015年底在意大利阻断本土麻疹传播。然而，2013年至2015年期间，意大利麻疹负担沉重，向强化麻疹监测系统报告了4902例麻疹病例（49.3%经实验室确诊）（三年参考期内的累积发病率：2.4/10万人口）。麻疹消除目标未实现。对麻疹流行基因型的实验室监测由位于罗马的意大利国家卫生研究院（Istituto Superiore di Sanità - ISS）的麻疹和风疹国家参考实验室（NRL）进行。对2013年1月1日至2015年12月31日期间收到的样本进行了分析。对通过分子检测呈麻疹基因组阳性的样本进行了测序和系统发育分析。NRL进行的系统发育分析确定，基因型D4和D8在2011 - 2013年为地方流行且共同传播：研究结果表明，基因型D4在2013年期间消失。2011 - 2013年期间，散发病例与基因型B3相关，该基因型在2014年在意大利成为地方流行，并与D8共同传播至2015年。在整个审查期间都发现有属于基因型D9和H1的散发病例。在世卫组织欧洲区域也观察到了类似趋势。
