Yang Hyejin, Yoon Minseok, Um Min Young, Lee Jaekwang, Jung Jonghoon, Lee Changho, Kim Yun-Tai, Kwon Sangoh, Kim Boknam, Cho Suengmok
Division of Functional Food Research, Korea Food Research Institute, Seongnam 13539, Korea.
S&D Research and Development Institute, Osong 28156, Korea.
Nutrients. 2017 May 18;9(5):512. doi: 10.3390/nu9050512.
Natural sleep aids are becoming more popular due to the widespread occurrence of sleep disorders. The objective of this study was to assess the sleep-promoting effects of rice bran-a product that is considered as a functional ingredient. To evaluate the sleep-promoting effects of a standardized rice bran supplement (RBS), we employed a pentobarbital-induced sleep test and conducted analyses of sleep architecture. In addition, the effect of RBS on a caffeine-induced sleep disturbance was investigated. Oral administration of RBS (500 and 1000 mg/kg) produced a significant decrease in sleep latency and increase in sleep duration in pentobarbital-induced sleep in mice. Moreover, both RBS (1000 mg/kg) and doxepin hydrochloride (histamine H₁ receptor antagonist, 30 mg/kg) counteracted a caffeine-induced sleep disturbance in mice. In terms of sleep phases, RBS (500 mg/kg) promoted non-rapid eye movement sleep for the first 3 h following its administration. Lastly, we unveiled a possible mechanism for RBS action as the hypnotic effect of RBS was blocked by a histamine H₁ receptor agonist. The present study revealed sleep-promoting effects of RBS using various animal assays. Such effects seem to be mediated through the histaminergic system. Our findings suggest that RBS may be a promising natural aid for relieving sleep problems.
由于睡眠障碍的广泛发生，天然睡眠辅助剂正变得越来越受欢迎。本研究的目的是评估米糠（一种被视为功能性成分的产品）的促睡眠效果。为了评估标准化米糠补充剂（RBS）的促睡眠效果，我们采用了戊巴比妥诱导的睡眠试验并对睡眠结构进行了分析。此外，还研究了RBS对咖啡因诱导的睡眠障碍的影响。口服RBS（500和1000毫克/千克）可使小鼠戊巴比妥诱导睡眠的睡眠潜伏期显著缩短，睡眠时间显著延长。此外，RBS（1000毫克/千克）和盐酸多塞平（组胺H₁受体拮抗剂，30毫克/千克）均可抵消咖啡因诱导的小鼠睡眠障碍。在睡眠阶段方面，RBS（500毫克/千克）在给药后的前3小时促进了非快速眼动睡眠。最后，由于RBS的催眠作用被组胺H₁受体激动剂阻断，我们揭示了RBS作用的一种可能机制。本研究通过各种动物试验揭示了RBS的促睡眠效果。这种效果似乎是通过组胺能系统介导的。我们的研究结果表明，RBS可能是缓解睡眠问题的一种有前景的天然辅助剂。
