Yoon Minseok, Kwon Sangoh, Um Min Young, Cho Suengmok
Food Functionality Research Division, Korea Food Research Institute, Wanju 55364, Republic of Korea.
S&D Research and Development Institute, Cheongju 28156, Republic of Korea.
J Microbiol Biotechnol. 2025 Aug 26;35:e2505010. doi: 10.4014/jmb.2505.05010.
This study aimed to investigate the effects of chronic administration of rice bran supplement (RBS) on sleep and to compare these effects with those of the hypnotic drug zolpidem (ZPD). During the three-week treatment period, ZPD initially reduced sleep latency, but that reduction effect of sleep latency gradually diminished over time and significantly decreased non-rapid eye movement sleep (NREMS). In contrast, RBS reduced sleep latency and increased NREMS on the first day, and these effects persisted throughout the treatment period. Additionally, RBS altered the time course of NREMS, which persisted until day 21. Importantly, while RBS did not affect delta activity during the treatment period, the ZPD group experienced a decrease in delta activity on the first day, which recovered by day 21. Our findings suggest that RBS does not induce tolerance during chronic administration and does not alter sleep architecture upon discontinuation, indicating that it could be utilized as a natural sleep aid suitable for long-term consumption.
本研究旨在探讨长期服用米糠补充剂（RBS）对睡眠的影响，并将这些影响与催眠药物唑吡坦（ZPD）的影响进行比较。在为期三周的治疗期间，ZPD最初缩短了睡眠潜伏期，但随着时间的推移，这种缩短睡眠潜伏期的效果逐渐减弱，并且显著减少了非快速眼动睡眠（NREMS）。相比之下，RBS在第一天就缩短了睡眠潜伏期并增加了NREMS，并且这些效果在整个治疗期间持续存在。此外，RBS改变了NREMS的时间进程，这种改变一直持续到第21天。重要的是，虽然RBS在治疗期间没有影响δ波活动，但ZPD组在第一天出现了δ波活动减少的情况，到第21天恢复。我们的研究结果表明，RBS在长期给药期间不会诱导耐受性，停药后也不会改变睡眠结构，这表明它可以用作适合长期服用的天然助眠剂。
