Bio-nanomaterials Chemistry and Engineering Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Rm H5229, Ottawa, Canada.
Laboratorio de Cinética y Fotoquímica, Departamento de Ciencias del Ambiente-Facultad de Química y Biología, Universidad de Santiago de Chile, Avenida Libertador Bernardo O'Higgins 3363, Santiago, Chile.
Analyst. 2017 Jun 21;142(12):2067-2089. doi: 10.1039/c7an00288b. Epub 2017 May 19.
The interaction between nanoparticles and molecules plays a key role in determining the activity and performance of a given nanostructure. These interactions are pivotal for a variety of applications including drug delivery, surface manipulation for targeted therapies, and catalysis. However, to this day, gathering precise association parameters for the interaction of the molecules with nanostructures remains elusive and mostly imprecise. In this review, we present a critical discussion of the most commonly used techniques and models intended for determining the association of molecules with nanoparticles. Particular emphasis has been put on discussing the limitations and pitfalls related to determining association constants in this tutorial review.
纳米粒子和分子之间的相互作用在决定给定纳米结构的活性和性能方面起着关键作用。这些相互作用对于包括药物输送、靶向治疗的表面操纵和催化在内的各种应用至关重要。然而，直到今天，对于分子与纳米结构相互作用的确切结合参数的收集仍然难以捉摸，而且大多不准确。在这篇综述中，我们对用于确定分子与纳米粒子结合的最常用技术和模型进行了批判性讨论。特别强调了在本教程综述中讨论确定结合常数的相关局限性和陷阱。
