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微/纳米马达在体内应用:细胞、组织和生物流体。

Micro/nanomotors towards in vivo application: cell, tissue and biofluid.

机构信息

Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands.

出版信息

Chem Soc Rev. 2017 Aug 29;46(17):5289-5310. doi: 10.1039/c6cs00885b.

Abstract

Inspired by highly efficient natural motors, synthetic micro/nanomotors are self-propelled machines capable of converting the supplied fuel into mechanical motion. A significant advance has been made in the construction of diverse motors over the last decade. These synthetic motor systems, with rapid transporting and efficient cargo towing abilities, are expected to open up new horizons for various applications. Utilizing emergent motor platforms for in vivo applications is one important aspect receiving growing interest as conventional therapeutic methodology still remains limited for cancer, heart, or vasculature diseases. In this review we will highlight the recent efforts towards realistic in vivo application of various motor systems. With ever booming research enthusiasm in this field and increasing multidisciplinary cooperation, micro/nanomotors with integrated multifunctionality and selectivity are on their way to revolutionize clinical practice.

摘要

受高效天然马达的启发,合成微/纳米马达是能够将供应燃料转化为机械运动的自推进机器。在过去十年中,在构建各种马达方面取得了重大进展。这些合成的马达系统具有快速运输和高效货物牵引能力,有望为各种应用开辟新的领域。利用新兴的马达平台进行体内应用是一个越来越受到关注的重要方面,因为传统的治疗方法仍然对癌症、心脏或血管疾病有限。在这篇综述中,我们将重点介绍各种马达系统在现实的体内应用方面的最新进展。随着该领域研究热情的不断高涨和多学科合作的不断增加,具有集成多功能性和选择性的微/纳米马达正在走向临床实践的革命化。

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