State Key Laboratory of Robotics and System (HIT), Micro/Nanotechnology Research Center, Harbin Institute of Technology, Harbin, 150080, China.
Small. 2016 Jun;12(23):3080-93. doi: 10.1002/smll.201503969. Epub 2016 Apr 13.
The combination of bottom-up controllable self-assembly technique with bioinspired design has opened new horizons in the development of self-propelled synthetic micro/nanomotors. Over the past five years, a significant advances toward the construction of bioinspired self-propelled micro/nanomotors has been witnessed based on the controlled self-assembly technique. Such a strategy permits the realization of autonomously synthetic motors with engineering features, such as sizes, shapes, composition, propulsion mechanism, and function. The construction, propulsion mechanism, and movement control of synthetic micro/nanomotors in connection with controlled self-assembly in recent research activities are summarized. These assembled nanomotors are expected to have a tremendous impact on current artificial nanomachines in future and hold potential promise for biomedical applications including drug targeted delivery, photothermal cancer therapy, biodetoxification, treatment of atherosclerosis, artificial insemination, crushing kidney stones, cleaning wounds, and removing blood clots and parasites.
基于可控自组装技术的自下而上的组合与仿生设计相结合，为自推进式合成微/纳米马达的发展开辟了新的前景。在过去的五年中，基于可控自组装技术，在构建基于仿生的自推进微/纳米马达方面取得了重大进展。这种策略允许实现具有工程特征（如尺寸、形状、组成、推进机制和功能）的自主合成马达。总结了与近期研究活动中可控自组装相关的合成微/纳米马达的构建、推进机制和运动控制。这些组装纳米马达有望对未来的人工纳米机器产生巨大影响，并为包括药物靶向输送、光热癌症治疗、生物解毒、动脉粥样硬化治疗、人工授精、肾结石粉碎、伤口清洁以及清除血栓和寄生虫在内的生物医学应用提供巨大潜力。
