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基于微纳马达副产物的主动疗法。

Active therapy based on the byproducts of micro/nanomotors.

作者信息

Liang Haiying, Peng Fei, Tu Yingfeng

机构信息

NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.

School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

出版信息

Nanoscale. 2023 Jan 19;15(3):953-962. doi: 10.1039/d2nr05818a.

Abstract

Different from traditional colloidal particles based on Brownian motion, micro/nanomotors are micro/nanoscale devices capable of performing complex tasks in liquid media transforming various energy sources into mechanical motion or actuation. Such unique self-propulsion endows motors with fantastic capabilities to access and enter the deep layer of targeted diseased tissue, which in turn breaks through the limitation of the poor permeability of traditional pharmaceutical preparations, thus providing giant prospects for active therapy. It is noteworthy that recently several studies, which utilized the byproducts generated by micro/nanomotors to achieve active therapy, in a truly green zero-waste manner, have been carried out. In this minireview, we highlight the recent efforts with respect to active therapy based on the byproducts of micro/nanomotors, expecting to motivate readers to expand the practical biomedical application scope of micro/nanomotors in a broader horizon. Accompanied by ever booming enthusiasm and persevering exploration, micro/nanomotors are on their way to revolutionize conventional fields.

摘要

与基于布朗运动的传统胶体颗粒不同,微纳马达是能够在液体介质中执行复杂任务的微纳尺度装置,可将各种能量源转化为机械运动或驱动。这种独特的自我推进能力赋予了马达进入和深入靶向病变组织深层的奇妙能力,进而突破了传统药物制剂渗透性差的限制,从而为主动治疗提供了巨大前景。值得注意的是,最近已经开展了几项研究,这些研究以真正绿色零废物的方式利用微纳马达产生的副产物来实现主动治疗。在本综述中,我们重点介绍了基于微纳马达副产物进行主动治疗的最新进展,期望激励读者在更广阔的视野中拓展微纳马达在生物医学领域的实际应用范围。伴随着日益高涨的热情和不懈的探索,微纳马达正朝着彻底改变传统领域的方向迈进。

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