饮酒与颈总动脉内膜中层厚度：美国内膜中层厚度研究
Alcohol Consumption and Common Carotid Intima-Media Thickness: The USE-IMT Study.
作者信息
Britton Annie R, Grobbee Diederick E, den Ruijter Hester M, Anderson Todd J, Desvarieux Moise, Engström Gunnar, Evans Greg W, Hedblad Bo, Kauhanen Jussi, Kurl Sudhir, Lonn Eva M, Mathiesen Ellisiv B, Polak Joseph F, Price Jacqueline F, Rembold Christopher M, Rosvall Maria, Rundek Tatjana, Salonen Jukka T, Stehouwer Coen, Tuomainen Tomi-Pekka, Bots Michiel L
机构信息
Department of Epidemiology and Public Health University College London, London WC1E 6BT, UK.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.
出版信息
Alcohol Alcohol. 2017 Jul 1;52(4):483-486. doi: 10.1093/alcalc/agx028.
AIMS
Epidemiological evidence indicates a protective effect of light to moderate alcohol consumption compared to non-drinking and heavy drinking. Although several mechanisms have been suggested, the effect of alcohol on atherosclerotic changes in vessel walls is unclear. Therefore, we explored the relationship between alcohol consumption and common carotid intima media thickness, a marker of early atherosclerosis in the general population.
METHODS
Individual participant data from eight cohorts, involving 37,494 individuals from the USE-IMT collaboration were used. Multilevel age and sex adjusted linear regression models were applied to estimate mean differences in common carotid intima-media thickness (CIMT) with alcohol consumption.
RESULTS
The mean age was 57.9 years (SD 8.6) and the mean CIMT was 0.75 mm (SD 0.177). About, 40.5% reported no alcohol consumed, and among those who drank, mean consumption was 13.3 g per day (SD 16.4). Those consuming no alcohol or a very small amount (<5 g per day) had significantly lower common CIMT values than those consuming >10 g per day, after adjusting for a range of confounding factors.
CONCLUSION
In this large CIMT consortium, we did not find evidence to support a protective effect of alcohol on CIMT.
目的
流行病学证据表明，与不饮酒和大量饮酒相比，轻度至中度饮酒具有保护作用。尽管已提出多种机制，但酒精对血管壁动脉粥样硬化变化的影响尚不清楚。因此，我们探讨了饮酒与普通人群早期动脉粥样硬化标志物——颈总动脉内膜中层厚度之间的关系。
方法
使用了来自八个队列的个体参与者数据，涉及USE-IMT合作项目中的37494名个体。应用多水平年龄和性别调整线性回归模型来估计饮酒与颈总动脉内膜中层厚度（CIMT）的平均差异。
结果
平均年龄为57.9岁（标准差8.6），平均CIMT为0.75毫米（标准差0.177）。约40.5%的人报告不饮酒，在饮酒者中，平均饮酒量为每天13.3克（标准差16.4）。在调整一系列混杂因素后，不饮酒或饮酒量极少（每天<5克）的人，其颈总动脉内膜中层厚度值显著低于每天饮酒量>10克的人。
结论
在这个大型CIMT联合研究中，我们没有发现证据支持酒精对CIMT具有保护作用。
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