Gastroenterology, University Hospital, 3010 Bern, Switzerland.
Hospital Universitario Ramón y Cajal, Gastroenterology and Hepatology, Madrid, Spain.
J Hepatol. 2017 Nov;67(5):1084-1103. doi: 10.1016/j.jhep.2017.05.007. Epub 2017 May 16.
The gut-liver axis is widely implicated in the pathogenesis of liver diseases, where it is increasingly the focus of clinical research. Recent studies trialling an array of therapeutic and preventative strategies have yielded promising results. Considering these strategies, the armamentarium for targeting the gut-liver axis will continue to expand. Further clinical trials, translated from our current knowledge of the gut-liver axis, promise an exciting future in liver treatment.
肠-肝轴广泛参与肝脏疾病的发病机制,越来越成为临床研究的重点。最近的研究尝试了一系列治疗和预防策略,取得了有希望的结果。考虑到这些策略,针对肠-肝轴的武器库将继续扩大。进一步的临床试验,从我们目前对肠-肝轴的了解转化而来,有望为肝脏治疗带来令人兴奋的未来。