Tandon Anika, Watson Caroline, Ayyala Ramesh
Pediatric Eye Associates, Tulsa, Oklahoma.
University of Alabama School of Medicine, University of Alabama, Birmingham, Alabama.
J AAPOS. 2017 Jun;21(3):234-237. doi: 10.1016/j.jaapos.2017.03.011. Epub 2017 May 18.
To compare the diameter of Schlemm's canal in children with and without congenital glaucoma as measured in vivo by means of ultrasound biomicroscopy.
In this prospective single-center study of pediatric subjects (<18 years of age) the diameter of Schlemm's canal in nonglaucomatous and glaucomatous eyes was compared. An 80 MHz iUltrasound probe (iScience Interventional Inc, Menlo Park, CA) placed near the limbus was used to identify and measure the canal's diameter with special attention to the anterior segment anatomy (especially in subjects with congenital glaucoma).
A total of 20 subjects were included; mean age of subjects without glaucoma was 6.6 ± 6.65 years; of those with glaucoma, 9.4 ± 11.80 months. The mean canal diameter in nonglaucomatous eyes was 142 ± 33.2 μm (range, 90-196 μm); in glaucomatous eyes, 64.9 ± 10.90 μm (P = 0.007). Schlemm's canal could not be identified in 50% of patients with congenital glaucoma. There was a trend toward smaller canal diameter in subjects with no glaucoma <2 years old. Mean canal diameter in nonglaucomatous eyes was 103 ± 8 μm (range, 90-115 μm) in subjects <2 years of age and 161 ± 20 μm (range, 110-196 μm) in subjects >2 years of age (P = 0.0012).
In our pediatric study cohort the diameter of Schlemm's canal varied by age and presence of glaucoma.
通过超声生物显微镜在体测量，比较患有和未患有先天性青光眼的儿童施莱姆管的直径。
在这项针对儿科受试者（<18岁）的前瞻性单中心研究中，比较了非青光眼和青光眼患者眼睛中施莱姆管的直径。使用放置在角膜缘附近的80MHz超声探头（iScience Interventional Inc，加利福尼亚州门洛帕克）识别并测量该管的直径，特别关注眼前段解剖结构（尤其是先天性青光眼患者）。
共纳入20名受试者；无青光眼受试者的平均年龄为6.6±6.65岁；青光眼患者的平均年龄为9.4±11.80个月。非青光眼患者眼睛中施莱姆管的平均直径为142±33.2μm（范围90 - 196μm）；青光眼患者眼睛中为64.9±10.90μm（P = 0.007）。50%的先天性青光眼患者无法识别施莱姆管。2岁以下无青光眼受试者的施莱姆管直径有变小的趋势。2岁以下受试者非青光眼眼睛中施莱姆管的平均直径为103±8μm（范围90 - 115μm），2岁以上受试者为161±20μm（范围110 - 196μm）（P = 0.0012）。
在我们的儿科研究队列中，施莱姆管的直径因年龄和青光眼的存在而有所不同。
