State Key Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.
The School of Chemistry & Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.
Int J Biol Macromol. 2017 Oct;103:554-574. doi: 10.1016/j.ijbiomac.2017.05.071. Epub 2017 May 19.
In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of science and medicine since it inactivates conventional antimicrobial therapeutics. Scientists are trying to respond to AMR/MDR threat by exploring innovative platforms and new therapeutic strategies to tackle infections from these resistant strains and bypass treatment limitations related to these pathologies. The present review focuses on the utilization of bio-inspired novel constructs and their potential applications as novel antimicrobial agents. The first part of the review describes plant-based biological macromolecules containing an immense variety of secondary metabolites, which could be potentially used as alternative strategies to combat antimicrobial resistance. The second part discusses the potential of metal-based macromolecules as effective antimicrobial platforms for preventing infections from resistant strains. The third part comprehensively elucidates how nanoparticles, in particular, metal-integrated nanoparticles can overcome this AMR or MDR issue. Towards the end, information is given with critical concluding remarks, gaps, and finally envisioned with future considerations.
近年来，抗菌药物耐药性（AMR）或多药耐药性（MDR）已成为全球范围内一个严重的健康问题和主要挑战。经过几十年的忽视，AMR 现在引起了全球的关注。由于抗生素耐药菌株的数量不断增加，它使传统的抗菌治疗方法失效，从而威胁到了科学和医学的成果。科学家们正在通过探索创新平台和新的治疗策略来应对 AMR/MDR 威胁，以解决这些耐药菌株引起的感染，并克服与这些疾病相关的治疗局限性。本综述重点介绍了仿生新型构建体的利用及其作为新型抗菌剂的潜在应用。综述的第一部分描述了含有大量次生代谢物的基于植物的生物大分子，这些生物大分子可能被用作对抗抗菌药物耐药性的替代策略。第二部分讨论了金属基大分子作为预防耐药菌株感染的有效抗菌平台的潜力。第三部分全面阐明了纳米粒子，特别是金属整合纳米粒子如何克服这一 AMR 或 MDR 问题。最后，给出了批判性的结论、差距信息，并对未来进行了展望。
