焦磷酸盐类似物对豚鼠皮肤单纯疱疹病毒1型感染的治疗作用。

Therapeutic effect of pyrophosphate analogues on cutaneous herpes simplex virus type 1 infection in guinea pigs.

作者信息

Wutzler P, Helbig B, Ulbricht A, Meerbach A, Pradel W

机构信息

Institute of Medical Microbiology, Medical Academy Erfurt, G.D.R.

出版信息

Antiviral Res. 1988 Nov;10(1-3):99-106. doi: 10.1016/0166-3542(88)90018-6.

DOI:10.1016/0166-3542(88)90018-6

PMID:2852923

Abstract

We investigated the influence of disodium phosphonic formate (PFA-Na2) and trisodium thiophosphonic formate (TPFA-Na3), in comparison with acyclovir (Zovirax) and trisodium phosphonic formate (PFA-Na3) (Triapten) ointment, on the course of primary cutaneous herpes simplex virus infection in a guinea pig skin model. PFA-Na2 at 3.0%, TPFA-Na3 at 0.5% and PFA-Na3 at 0.5% as well as Triapten ointment (2.0% PFA-Na3) completely inhibited virus infection. Zovirax cream (5.0% acyclovir), applied five times (15 min., 4, 20, 24, and 28 h) after virus inoculation did not prevent virus infection. Similarly, application of Zovirax cream 5 times daily for 5 days did not prevent a vesicle formation following cutaneous herpes simplex virus infection of the guinea pig.

摘要

我们在豚鼠皮肤模型中，研究了膦甲酸钠二钠（PFA-Na2）和硫代膦甲酸钠三钠（TPFA-Na3），与阿昔洛韦（昔洛韦）和膦甲酸钠三钠（PFA-Na3）（三磷腺苷）软膏相比，对原发性皮肤单纯疱疹病毒感染病程的影响。3.0%的PFA-Na2、0.5%的TPFA-Na3、0.5%的PFA-Na3以及三磷腺苷软膏（2.0% PFA-Na3）完全抑制了病毒感染。在病毒接种后5次（分别于15分钟、4小时、20小时、24小时和28小时）涂抹昔洛韦乳膏（5.0%阿昔洛韦）并不能预防病毒感染。同样，豚鼠皮肤单纯疱疹病毒感染后，每天5次涂抹昔洛韦乳膏，持续5天，也不能预防水疱形成。