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豚鼠皮肤单纯疱疹病毒感染：局部治疗后对阿昔洛韦和膦甲酸缺乏抗性

Cutaneous herpes simplex virus infection of the guinea pig: lack of resistance to acyclovir and phosphonoformic acid after topical treatment.

作者信息

Poryo A, Wigand R

出版信息

Med Microbiol Immunol. 1984;173(4):219-24. doi: 10.1007/BF02122113.

DOI:10.1007/BF02122113
PMID:6096685
Abstract

Guinea pigs were infected cutaneously with HSV1 and treated topically with acyclovir or phosphonoformic acid (0.1% to 0.5% solution), or with a combination of both. The therapy was clinically effective and the virus content in the skin diminished. Virus harvests from skin areas in no case showed increased drug resistance, as tested by plaque reduction.

摘要

将豚鼠经皮肤感染单纯疱疹病毒1型，然后局部用阿昔洛韦或膦甲酸（0.1%至0.5%溶液）治疗，或两者联合使用。该疗法临床有效，皮肤中的病毒含量减少。通过蚀斑减少试验检测，从皮肤区域收获的病毒在任何情况下均未显示出耐药性增加。

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Cutaneous herpes simplex virus infection of the guinea pig: lack of resistance to acyclovir and phosphonoformic acid after topical treatment.豚鼠皮肤单纯疱疹病毒感染：局部治疗后对阿昔洛韦和膦甲酸缺乏抗性
Med Microbiol Immunol. 1984;173(4):219-24. doi: 10.1007/BF02122113.
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Combined chemotherapy of cutaneous herpes simplex infection of the guinea pig.豚鼠皮肤单纯疱疹感染的联合化疗
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Comparison of foscarnet cream, acyclovir cream, and acyclovir ointment in the topical treatment of experimental cutaneous herpes simplex virus type 1 infection.膦甲酸钠乳膏、阿昔洛韦乳膏和阿昔洛韦软膏在实验性皮肤单纯疱疹病毒1型感染局部治疗中的比较。
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Therapeutic effects of foscarnet sodium and acyclovir on cutaneous infections due to herpes simplex virus type 1 in guinea pigs.膦甲酸钠与阿昔洛韦对豚鼠1型单纯疱疹病毒所致皮肤感染的治疗作用
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Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with trifluorothymidine, phosphonoformate and acycloguanosine against herpes simplex viruses.联合化疗：5-甲氧基甲基脱氧尿苷与三氟胸苷、膦甲酸和阿昔洛韦对单纯疱疹病毒的相互作用
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[Efficacy of cidofovir in an HIV infected patient with an acyclovir and foscarnet resistant herpes simplex virus infection].西多福韦治疗一名对阿昔洛韦和膦甲酸钠耐药的单纯疱疹病毒感染的HIV感染患者的疗效
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Topical phosphonoacetic acid treatment of cutaneous herpes simplex infections in the guinea pig.局部应用膦甲酸钠治疗豚鼠皮肤单纯疱疹感染
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引用本文的文献

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Small Animal Models to Study Herpes Simplex Virus Infections.小动物模型用于研究单纯疱疹病毒感染。
Viruses. 2024 Jun 27;16(7):1037. doi: 10.3390/v16071037.

本文引用的文献

1
Suppression of frequently recurring genital herpes. A placebo-controlled double-blind trial of oral acyclovir.复发性生殖器疱疹的抑制作用。口服阿昔洛韦的安慰剂对照双盲试验。
N Engl J Med. 1984 Jun 14;310(24):1545-50. doi: 10.1056/NEJM198406143102401.
2
Antiherpes drugs: promises and pitfalls.抗疱疹药物：前景与陷阱
Eur J Clin Microbiol. 1984 Apr;3(2):96-107. doi: 10.1007/BF02014325.
3
Frequency and significance of acyclovir-resistant herpes simplex virus isolated from marrow transplant patients receiving multiple courses of treatment with acyclovir.
从接受多疗程阿昔洛韦治疗的骨髓移植患者中分离出的阿昔洛韦耐药单纯疱疹病毒的频率及意义。
J Infect Dis. 1983 Dec;148(6):1077-82. doi: 10.1093/infdis/148.6.1077.
4
In vitro sensitivity to acyclovir in genital herpes simplex viruses from acyclovir-treated patients.接受阿昔洛韦治疗患者的生殖器单纯疱疹病毒对阿昔洛韦的体外敏感性
J Infect Dis. 1983 Nov;148(5):868-75. doi: 10.1093/infdis/148.5.868.
5
Pathogenicity of acyclovir-resistant herpes simplex virus type 1 from an immunodeficient child.一名免疫缺陷儿童体内耐阿昔洛韦的1型单纯疱疹病毒的致病性
J Infect Dis. 1982 Nov;146(5):673-82. doi: 10.1093/infdis/146.5.673.
6
Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates.临床分离株中存在对高浓度阿昔洛韦耐药的单纯疱疹病毒变种。
Antimicrob Agents Chemother. 1982 Jul;22(1):71-7. doi: 10.1128/AAC.22.1.71.
7
Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)-2'-deoxyuridine: a physical analysis.单纯疱疹病毒对阿糖腺苷和E-5-（2-溴乙烯基）-2'-脱氧尿苷的抗性：一项物理分析。
J Infect Dis. 1982 Aug;146(2):167-72. doi: 10.1093/infdis/146.2.167.
8
Pathogenesis of experimental skin infections induced by drug-resistant herpes simplex virus mutants.耐药单纯疱疹病毒突变体诱导的实验性皮肤感染的发病机制
Infect Immun. 1981 Dec;34(3):693-701. doi: 10.1128/iai.34.3.693-701.1981.
9
Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir.从接受阿昔洛韦治疗的患者中分离出的单纯疱疹病毒对抗病毒药物的耐药性。
N Engl J Med. 1982 Feb 11;306(6):343-6. doi: 10.1056/NEJM198202113060606.
10
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.1型单纯疱疹病毒的阿昔洛韦耐药突变体表现出DNA聚合酶改变或阿昔洛韦磷酸化活性降低。
J Virol. 1981 Dec;40(3):936-41. doi: 10.1128/JVI.40.3.936-941.1981.