Ichimura H, Yamasaki M, Yamane T, Shimizu H, Katsumoto T, Kurimura O, Kurimura T
Institute of Clinical Research, Kure National Hospital.
Jpn J Cancer Res. 1988 Dec;79(12):1255-8. doi: 10.1111/j.1349-7006.1988.tb01552.x.
Argyrophil small cell carcinoma of the uterine cervix (ASCC) containing human papillomavirus type 16 (HPV16) DNA has been successfully transplanted in nude mice for the first time, and we have designated the resultant cell line as YIK-1. Histology of YIK-1 was similar to that of the original tumor. The original and YIK-1 tumor cells contained argyrophil granules and neurosecretory granules in the cytoplasm, and were immunohistochemically stained positive for neuron-specific enolase, serotonin and chromogranin. Both tumors contained HPV16 DNA in a multiple-copy integrated form. Thus, YIK-1 maintains the characteristics of the original ASCC, and may therefore be useful as an animal system for experimental studies of ASCC.
首次成功地将含有16型人乳头瘤病毒（HPV16）DNA的子宫颈嗜银性小细胞癌（ASCC）移植到裸鼠体内，我们将由此产生的细胞系命名为YIK-1。YIK-1的组织学与原发肿瘤相似。原发肿瘤和YIK-1肿瘤细胞的细胞质中均含有嗜银颗粒和神经分泌颗粒，免疫组织化学染色显示神经元特异性烯醇化酶、血清素和嗜铬粒蛋白呈阳性。两种肿瘤均含有多拷贝整合形式的HPV16 DNA。因此，YIK-1保留了原发ASCC的特征，因而可能作为ASCC实验研究的动物模型。
