Wang Shengyu, Wang Yiyun, Song Liyang, Chen Jiaxin, Ma Yujie, Chen Yunbin, Fan Shunwu, Su Miaoshang, Lin Xianfeng
Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, China.
Mater Sci Eng C Mater Biol Appl. 2017 Aug 1;77:1290-1301. doi: 10.1016/j.msec.2017.03.279. Epub 2017 Mar 31.
Tendon injuries impose significant clinical burdens on healthcare systems worldwide. At present, no therapeutic methods can cure tendon injuries in an ideal manner. With the development and improvement of decellularization technology, tendon extracellular matrix (ECM) can develop into novel scaffolds with potential for repairing injured tendons. Proper agents and decellularization protocols were developed to obtain tendon ECMs, and the method used to recellularize the tendon ECM was explored to create bio-functional neo-tendons for transplants. Further, preliminary testing was done to evaluate the reparative capacity of decellularized tendon scaffolds (DTSs). Here, we assess developments in tendon decellularization and recellularization processes, as well as the possibility for advancing DTSs into clinical applications based on recent findings.
肌腱损伤给全球医疗系统带来了巨大的临床负担。目前，尚无治疗方法能理想地治愈肌腱损伤。随着去细胞技术的发展与完善，肌腱细胞外基质（ECM）可开发成为具有修复损伤肌腱潜力的新型支架。人们开发了合适的试剂和去细胞方案来获取肌腱ECM，并探索了使肌腱ECM重新细胞化的方法，以创建用于移植的生物功能新肌腱。此外，还进行了初步测试以评估去细胞肌腱支架（DTSs）的修复能力。在此，我们根据近期研究结果评估肌腱去细胞化和重新细胞化过程的进展，以及将DTSs推进到临床应用的可能性。
