Vanotti Sandra, Smerbeck A, Eizaguirre María B, Saladino Maria L, Benedict Ralph R H, Caceres Fernando J
a Multiple Sclerosis Clinic , INEBA - Neurosciences Institute of Buenos Aires , Buenos Aires , Argentina.
b Department of Psychology , Rochester Institute of Technology , Rochester , New York , USA.
Appl Neuropsychol Adult. 2018 Sep-Oct;25(5):424-433. doi: 10.1080/23279095.2017.1323751. Epub 2017 May 23.
The Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) was developed to provide valid assessment of cognitive impairment in multiple sclerosis (MS). The relationship between clinical and social variables and cognitive disorders has been extensively studied, but primarily in developed countries with a focus on other cognitive measures or batteries. The objectives of this study were to analyze the relationship between the BICAMS data and key clinical and sociodemographic variables in the Argentine MS population. A total of 50 MS patients were administered the Argentinean BICAMS Battery, comprised of the Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test I (CVLT I), and the Brief Visuospatial Memory Test Revised (BVMTR). Disease progression, fatigue, depression, self-reported and informant report cognitive status, and employment status were assessed. Disease progression and employment status were most strongly associated with overall BICAMS performance (η effect size values ranging from .302 to .624, all comparisons statistically significant). Informant rating of patient cognition, age, depression, disease duration, fatigue, and work hours were significantly associated as well. Gender, years of education, and patient-reported cognitive status were nonpredictive. A similar pattern was seen at the individual test level, with more variables related to the SDMT and CVLT I than BVMTR. BICAMS is strongly associated with overall disease progression and employment status.
简短国际多发性硬化认知评估量表（BICAMS）旨在对多发性硬化（MS）患者的认知障碍进行有效评估。临床和社会变量与认知障碍之间的关系已得到广泛研究，但主要集中在发达国家，且侧重于其他认知测量方法或量表。本研究的目的是分析阿根廷MS患者群体中BICAMS数据与关键临床及社会人口统计学变量之间的关系。共有50名MS患者接受了阿根廷版BICAMS量表测试，该量表包括符号数字模式测验（SDMT）、加利福尼亚言语学习测验第一版（CVLT I）和修订版简短视觉空间记忆测验（BVMTR）。对疾病进展、疲劳、抑郁、自我报告及他人报告的认知状态以及就业状况进行了评估。疾病进展和就业状况与BICAMS总体表现的相关性最强（η效应量值范围为0.302至0.624，所有比较均具有统计学意义）。他人对患者认知的评分、年龄、抑郁、病程、疲劳和工作时长也存在显著相关性。性别、受教育年限和患者自我报告的认知状态无预测价值。在单项测试层面也观察到类似模式，与SDMT和CVLT I相关的变量多于BVMTR。BICAMS与总体疾病进展和就业状况密切相关。
