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鱼类、两栖类和爬行类动物局部麻醉剂的用途及剂量

Uses and Doses of Local Anesthetics in Fish, Amphibians, and Reptiles.

作者信息

Chatigny Frederic, Kamunde Collins, Creighton Catherine M, Stevens E Don

机构信息

Departments of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward, Charlottetown, Prince Edward, Canada;, Email:

Departments of Biomedical Sciences, Atlantic Veterinary College, University of Prince Edward, Charlottetown, Prince Edward, Canada.

出版信息

J Am Assoc Lab Anim Sci. 2017 May 1;56(3):244-253.

Abstract

Local anesthetics are an integral part of routine pain management in mammals, yet their use is relatively limited in fish, amphibians and reptiles. These animals frequently undergo potentially painful surgical procedures and therefore could possibly benefit from those drugs. Some recommendations are currently available in the literature concerning analgesic use in these animals. However the pharmacological properties, safety and often efficacy of local anesthetic drugs have not been investigated yet in fish, amphibians, or reptiles. This review compiled current information concerning the use of those agents in fish, reptiles and amphibians to help clinicians make an informed decision as to which dose and drug to use. The resulting literature search showed that the literature concerning use of local analgesics in fish and amphibians is very limited while the literature for reptiles is more extensive. We found few experimental studies evaluating the efficacy of local anesthetics. Further studies would provide additional information for developing guidelines to improve the welfare of fish, amphibians and reptiles.

摘要

局部麻醉药是哺乳动物常规疼痛管理的重要组成部分,但它们在鱼类、两栖动物和爬行动物中的应用相对有限。这些动物经常接受可能会引起疼痛的外科手术,因此可能会从这些药物中受益。目前文献中有一些关于这些动物使用镇痛药的建议。然而,局部麻醉药在鱼类、两栖动物或爬行动物中的药理特性、安全性以及通常的疗效尚未得到研究。这篇综述汇编了有关这些药物在鱼类、爬行动物和两栖动物中使用的当前信息,以帮助临床医生就是使用哪种剂量和药物做出明智的决定。结果文献检索表明,关于鱼类和两栖动物使用局部镇痛药的文献非常有限,而关于爬行动物的文献则更为广泛。我们发现很少有评估局部麻醉药疗效的实验研究。进一步的研究将为制定改善鱼类、两栖动物和爬行动物福利的指南提供更多信息。

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